Administrative Core

摘要-行政核心（核心A） 发展和过度活跃的Ras肿瘤（DHART）孢子于2015年获得资助，目标是 对以NF 1为特征的肿瘤和癌症实施有效的靶向分子疗法 通过进行综合的、基于机制的转化研究来进行突变。在我们的研究中， 更新将继续解决癌症中过度活跃的Ras信号传导的基本问题。的 该计划包括三个研究项目和三个核心组成部分。人道主义援助和培训司的创新方面 SPORE包括：（1）专注于推进孤儿疾病患者的科学和护理;（2）强大的 重点关注儿童、青少年和年轻人发生的肿瘤;（3）各种肿瘤的研究 共享一个共同的驱动突变的类型;以及，（4）来自领先研究的调查团队 中心，以促进临床前和临床试验专业知识和患者访问的整合。 行政核心的目标是为所有计划提供科学和行政监督 的组成部分。这一核心是所有行政活动的中心点， 基本服务，包括作为协调、整合和沟通的组织单位， 所有组件。这些协调组成部分包括：1）提供总体组织框架， 研究人员沟通和互动/协作，2）管理财务，3）支持协调 研究项目、科学核心和发展计划（DRP和 CEP），4）与外部和内部咨询委员会成员协商，5）协调 DHART SPORE的数据集成和分析，以及6）继续建立和完善基础设施 支持有意义地共享我们与其他内部和外部机构的研究所产生的数据和信息， 外部NF协作联盟。

ABSTRACT – ADMINISTRATIVE CORE (CORE A) The Developmental and Hyperactive Ras Tumor (DHART) SPORE was funded in 2015 with the goal of implementing effective targeted molecular therapies for neoplasms and cancers characterized by NF1 mutations by conducting integrated, mechanistically based translational research. The studies proposed in our renewal will continue to address the fundamental problem of hyperactive Ras signaling in cancer. The program consists of three research projects and three core components. Innovative aspects of the DHART SPORE include: (1) a focus on advancing the science and care of patients with orphan diseases; (2) a strong emphasis on tumors arising in young children, adolescents, and young adults; (3) studies of diverse tumor types that share a common driver mutation; and, (4) an investigative team drawn from leading research centers across the nation to promote integration of preclinical and clinical trials expertise and patient access. The goal of the Administrative Core is to provide scientific and administrative oversight for all the program components of the DHART SPORE. This core serves as the central point for all administrative activities and essential services, including being the organizing unit for the coordination, integration and communication for all components. These coordinating components include: 1) providing the overall organizational framework by which researchers communicate and interact/collaborate, 2) managing finances, 3) supporting the coordination of the review of progress of the research projects, scientific cores and developmental programs (DRP and CEP), 4) consulting with the members of the External and Internal Advisory boards, 5) coordinating the overall data integration and analysis of the DHART SPORE, and 6) continuing to establish and refine the infrastructure to support the meaningful sharing of data and information generated through our studies with other internal and external NF-collaborative consortiums.