Exposure to volatile organic compounds and glycemic dysregulation among oil spill cleanup workers

项目摘要 糖尿病，血糖失调的临床表现，导致毁灭性的并发症，以及 对个人和社会来说，医疗费用都很高。糖尿病的患病率正在上升， 在某些少数群体中，特别是在社会经济地位低下的少数群体中， 在这些人群中的地位。有限的证据表明，环境因素的作用，在病因 血糖失调，并强调需要进一步的研究，以更好地了解这些关系。 暴露于BTEX-H（苯、甲苯、二甲苯、二甲苯和己烷）混合物是普遍存在的， 在流行病学和毒理学研究中与血糖失调有关，但在 文学作品一个差距是在评估和分析暴露方面;以前的工作主要涉及 BTEX-H化学品单独使用，而不是所有的BTEX-H化学品都进行了研究。相比之下 BTEX-H化学品通常是共同经历的，必须进行相应的分析。此外，以前的工作 并没有纳入具有大规模和不同暴露的个人，因此难以隔离 暴露效应拟议的研究将通过分析这些关联来解决这些差距- 使用混合物分析的具有广泛暴露范围的溢油工人的特征性、前瞻性队列 方法.本提案的目标是：a）检查BTEX-H混合物对以下人群的真实暴露影响： 在一组石油泄漏工人中，暴露后10年内发生糖尿病，B）以确定种族/民族 和社会经济类别的特定暴露负担，结果负担，以及BTEX-H混合物对临床 糖尿病协会，和c）检查BTEX-H混合物暴露对血糖失调的影响， 将混合物与i）糖化血红蛋白水平和ii）糖化血红蛋白水平的变化相关联 在两个时间点之间，间隔长达5年。 我的培训计划将使我能够进一步发展完成拟议研究所需的技能， 作为一名独立的研究人员追求成功的职业生涯。这些技能是a）在接触中变得流利 混合物理论和分析方法; B）发展操作社会经济和种族 在定量研究中的差距过程; c）进一步发展必要的技能，以加强科学研究 通过完善我的书面交流，扩大我的专业合作网络，并进一步 发展我的演讲策略;以及d）在负责任的研究行为方面获得额外的培训， 特别是在灾害和环境流行病学研究方面。这次训练会让我 我的目标是研究在灾害、环境和自然灾害的交叉点上的长期健康结果， 暴露和社会差异过程。

Project Abstract Diabetes, the clinical manifestation of glycemic dysregulation, leads to devastating complications as well as high medical costs for both the individual and society. Diabetes is increasing in prevalence and is disproportionately high among certain minority populations, and particularly among those of low socioeconomic status within those populations. Limited evidence suggests a role of environmental factors in the etiology of glycemic dysregulation and highlights the need for further research to better understand these relationships. Exposure to the BTEX-H (benzene, toluene, ethylbenzene, xylenes, and hexane) mixture is ubiquitous and is associated with glycemic dysregulation in epidemiologic and toxicological studies, but there are clear gaps in the literature. One gap is in the assessment and analysis of exposures; previous work primarily addresses the BTEX-H chemicals singly, and not all of the BTEX-H chemicals have been investigated as such. In contrast the BTEX-H chemicals are often experienced jointly and must be analyzed accordingly. Additionally, previous work has not incorporated individuals with large magnitude and varied exposures, making it difficult to isolate exposure effects. The proposed research will address these gaps by analyzing these associations in a well- characterized, prospective cohort of oil-spill workers with a wide range of exposures using mixtures analysis methods. The goals of this proposal are a) to examine real-world exposure effects of BTEX-H mixtures on incident diabetes up to 10 years post-exposure among a cohort of oil spill workers, b) to determine racial/ethnic and socioeconomic category specific exposure burden, outcome burden, and BTEX-H mixture to clinical diabetes associations, and c) to examine the effect of BTEX-H mixture exposure on glycemic dysregulation by relating the mixture to i) glycosylated hemoglobin levels and ii) change in glycosylated hemoglobin levels between two time points up to 5 years apart. My training plan will allow me to further develop the skills necessary to complete the proposed research and to pursue a successful career as an independent researcher. These skills are a) to become fluent in exposure mixtures theory and analysis methods; b) to develop skills in operationalizing socioeconomic and racial disparities processes in quantitative research; c) to further develop skills necessary for a strong scientific career by refining my written communication, expanding my professional network for collaboration, and further evolving my presentation strategies; and d) to obtain additional training in the responsible conduct of research, especially in the context of disaster and environmental epidemiology research. This training will propel me toward my goal of studying long-term health outcomes at the intersection of disasters, environmental exposures, and social disparities processes.