BLR&D Research Career Scientist Application

神经退行性疾病[例如阿尔茨海默病(AD)和帕金森病(PD)]是一组 由大脑不同区域神经元的渐进性死亡引起的破坏性情况。在……上面 另一方面，多发性硬化症(MS)是最常见的中枢神经系统自身免疫性疾病 系统，导致少突胶质细胞死亡和脱髓鞘。我们的实验室主要研究中枢神经系统 导致帕金森病和阿尔茨海默病患者神经元死亡的中枢神经系统细胞信号 多发性硬化症(MS)的疾病(AD)和脱髓鞘。所有这些障碍的特点是 中枢神经系统胶质细胞(星形胶质细胞和小胶质细胞)激活，过量产生不同的促炎因子 中枢神经系统内的分子，以及少突胶质细胞(MS)或神经元(AD和PD)的死亡。从几个 角度，我们一直在研究胶质细胞被激活以释放不同的 促炎症分子和神经毒素诱导神经细胞凋亡和死亡 少突胶质细胞。我们还参与识别神经胶质细胞可能通过的信号通路 以产生神经保护分子，神经干细胞可以被驱使向神经元和 神经退行性变中枢神经系统内的髓鞘生成细胞(少突胶质细胞)。最后，我们正在努力 在不同动物中抑制神经毒性信号通路和/或增强神经保护信号通路 通过无毒药物建立神经退行性疾病模型，以实现神经保护。因为有很多人 退伍军人患有痴呆症、AD、PD和MS，这些研究的结果将直接帮助退伍军人。 1

Neurodegenerative disorders [e.g. Alzheimer's disease (AD) and Parkinson's disease (PD)] are a group of devastating conditions that are caused by progressive death of neurons in different regions of the brain. On the other hand, multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system, resulting in oligodendrocytes death and demyelination. Our lab primarily focuses on central nervous system (CNS) cell signaling that leads to neuronal death in Parkinson's disease (PD) and Alzheimer's disease (AD) and demyelination in multiple sclerosis (MS). All these disorders are characterized by activation of CNS glial cells (astroglia and microglia), excessive production of different proinflammatory molecules within the CNS, and death of either oligodendroglia (MS) or neurons (AD and PD). From several angles, we have been investigating mechanisms by which glial cells are activated to release different proinflammatory molecules and neurotoxins for inducing apoptosis and cell death in neurons and oligodendroglia. We are also involved in identifying signaling pathways by which glial cells may be redirected to produce neuroprotective molecules and neural stem cells could be driven towards neurons and myelin-producing cells (oligodendrocytes) within the neurodegenerative CNS. Finally, we are trying to suppress neurotoxic signaling pathways and/or boost neuroprotective signaling pathways in different animal models of neurodegenerative diseases by nontoxic drugs in order to achieve neuroprotection. Since many veterans are suffering from dementia, AD, PD, and MS, results from these studies will directly help veterans. 1