An Integrated Life-Course Approach for Person-Centred Solutions and Care for Ageing with Multimorbidity in the European Regions - STAGE; Stay Healthy Through Ageing (STAGE)

STAGE的目的是展示生命过程方法的重要性和可行性，以防止加速老化，如多种疾病的积累所定义的，并将知识纳入可转移的以人为本的解决方案，以早期诊断和筛查，治疗和长期管理多种疾病。为了实现这一目标，STAGE提出了一种生命过程方法，以更好地了解具有多种发病率的老龄化，提供基于证据的解决方案，以支持医疗保健的转型，以应对未来深刻的健康和人口挑战。该方法利用欧洲的纵向队列和生物库的合作，跨越整个生命过程，采取行动的麻烦和疾病网络轨迹分析，以及衰老的生物学，探索一个人如何发展衰老与多种发病率。该项目的目标整合了伦理，社会，历史和基础设施框架;环境，流行病学和生物生命过程方法;人工智能驱动的综合以人为本的解决方案和应用;基于队列的临床研究;以及FAIR（可查找，可访问，可互操作和可重复使用）生命过程健康和地理空间数据门户网站，具有强大的管理，传播，参与和开发活动。STAGE的循证方法将在芬兰和德国的纵向队列中转化为以人为本的预防和护理干预，与公民、患者、医疗保健提供者、中小企业和政策制定者共同设计。它还将纳入社会科学和人文科学，并使利益攸关方参与制定邻里健康老龄化指数，以人为本的多种发病率预测，以及医疗保健和政策建议。最终，STAGE将为敏捷，高质量，以人为本的健康和护理服务创造解决方案，这些服务对生命过程和性别敏感，以需求为基础，旨在提高弹性和参与度。

STAGE aims to demonstrate the importance and feasibility of a life-course approach to prevent accelerated ageing, as defined by the accumulation of multi-morbidity, and to integrate knowledge into transferable person-centred solutions for early diagnosis and screening, treatment and long-term management of multi-morbidity. To achieve this, STAGE is proposing a life-course approach to better understand ageing with multi-morbidity, providing evidence-based solutions to support the transformation of healthcare to address the profound health and demographic challenges ahead. The approach capitalises on European collaborations of longitudinal cohorts and biobanks spanning the entire life-course, actioning exposome and disease networks trajectory analysis, as well as, the biology of ageing, to explore how a person develops ageing with multi-morbidity. The project objectives integrate an ethical, social, historical, and infrastructural framework; environmental, epidemiological and biological life-course approaches; artificial intelligence powered integrated person centred solutions and applications; cohort-based clinical studies; and a FAIR (findable, accessible, interoperable and reusable) life-course health and geospatial data portal with robust management, dissemination, engagement and exploitation activities. STAGE's evidence based methods will translate into a person-centred prevention and care intervention in longitudinal cohorts in Finland and Germany, co designed with citizens, patients, healthcare providers, SMEs, and policymakers. It will also embed social sciences and humanities and engage stakeholders to develop a neighbourhood healthy ageing index, person-centred predictions of multi-morbidity, and healthcare and policy recommendations. Ultimately, STAGE will create solutions for agile, high-quality, person-centred health and care services that are life-course and gender sensitive, needs-based, and designed to enhance resilience and participation.