Animal Production Core

酒精和其他物质滥用仍然是巨大的公共卫生问题， 在美国每年的成本接近5亿美元。尽管有一些重大的尝试 预防，更好地理解遗传和环境因素会增加 酒精使用障碍的风险，这种风险背后的神经回路，以及调节 这些电路在治疗上仍然是迫切需要的。在解决这一关键需求时，这 动物生产核心将继续提供P和HAD1大鼠，以及CHAP小鼠 印第安纳州酒精公司的调查人员说，这些酒是为高自愿酒精而选择性培育的 研究中心(IARC)或印第安纳大学-印第安纳波利斯普渡大学(IUPUI) 校园里。这些线条在啮齿动物中是不常见的，因为它们摄入过量的酒精， 例如，CHAP小鼠在简单的自愿饮酒期间达到250 mg/dl以上的BECs。 我们还将维持LAP3的群体，以及非选择性繁殖的Wistar大鼠和近亲繁殖的Wistar大鼠 以C57BL/6J小鼠为对照。这一核心是30多年来 具有选育、维持繁育群体和解决问题的经验 与运作这种规模的行动的后勤和性质有关。因此，我们是 在即将到来的资助期内独一无二地有资格继续向 酒精中毒和成瘾研究人员，协调使用动物，避免科学 重叠，并处理可能影响其表型和相关行为的问题。这个 动物生产核心将继续将这些系列描述为上瘾的动物模型 并促进它们在研究物质的遗传和神经生物学底物方面的使用 使用、滥用和依赖。

Alcohol and other substance abuse continue to be enormous public health issues with total costs in the US approaching a half billion dollars a year. Although there are major attempts at prevention, a better understanding of the genetic and environmental factors that increase the risk of alcohol use disorders, the neural circuits that underlie this risk, and the ability to regulate these circuits therapeutically are all still critically needed. In addressing this critical need, this Animal Production Core will continue to provide the P and HAD1 rats, along with cHAP mice that have been selectively bred for high voluntary alcohol, to investigators in the Indiana Alcohol Research Center (IARC) or on the Indiana University–Purdue University at Indianapolis (IUPUI) campus. These lines are unusual among rodents due to their excessive alcohol intake, with cHAP mice, for example, reaching BECs over 250 mg/dl during simple voluntary alcohol access. We will also maintain colonies of LAP3, along with non-selectively bred Wistar rats and inbred C57Bl/6J mice for comparison purposes. This Core is the outgrowth of over 30 years of experience with selective breeding, maintenance of breeding colonies, and solving problems arising with the logistics and nature of running an operation of this magnitude. We are therefore uniquely qualified in the coming funding period to continue to provide these animals to alcoholism and addiction researchers, to coordinate the use of the animals to avoid scientific overlap, and to manage issues that could affect their phenotype and associated behaviors. The Animal Production Core will continue to characterize these lines as animal models of addiction and promote their use in examining the genetic and neurobiological substrates of substance use, abuse and dependence.