Outreach Core

外展。项目摘要。 ST-Analytics科学计划旨在采用系统生物学的方法来解决 如何有效地给予靶向抑制剂-免疫疗法序贯联合治疗的问题 实体瘤的治疗，重点是黑色素瘤。ST Analytics采用了最先进的技术 实验和计算程序相互紧密反馈，朝着稳健的方向发展 解决方案。科技分析推广计划是一项高度互补性的计划，与STEM 与U54的核心科学主题相一致的外联目标。外展计划利用 在ISB的“系统教育体验”教师教育项目中，促进系统方法 通过开发教育模块来解决科学问题，这些模块提供了积极的STEM 为全球以及美国50个州的数百万学生提供学习体验。特别强调的是 传统上致力于向学生群体提供系统免疫肿瘤学实习和体验 在STEM字段中表示不足。基本方法是将这些实习生与ST-Analytics整合 研究人员将系统免疫肿瘤学概念纳入两个现有或正在开发的教育 模块，标题为系统医学模块3-个性化疾病治疗，并通过 系统思维与计算建模。虽然这些模块旨在满足下一代 科学标准(NGSS)，通常负责执行这些标准的专业教育工作者 没有适合这项工作的适当背景或支持材料。因此，我们的外展计划也是 旨在提供这一背景和支持。例如，我们提供基于研究、现实驱动的 每年为1,000多名教师和80名地区行政人员提供专业发展，影响超过 华盛顿三分之二的学生。因此，ST-Analytics推广计划的潜在影响是巨大的， 并通过利用遍及整个州的广泛现有资源和关系来实现 华盛顿州和美国西海岸的上下。向所有参与者征集创造性参与的计划 在我们建议的所有级别的U54计划中都有描述。

Outreach. Project Summary. The ST-Analytics scientific program is designed to take a systems biology approach towards addressing the question of how to effectively administer targeted-inhibitor – immunotherapy sequential combinations for the treatment of solid tumors, with an emphasis on melanoma. ST Analytics incorporates state-of-the-art experimental and computational programs advancing in close feedback with each other towards a robust solution. The ST-Analytics Outreach Program is designed as a highly complementary program, with STEM outreach goals that are aligned with the core scientific theme of the U54. The Outreach program takes advantage of ISB’s ‘Systems Education Experiences’ teacher Educational Programs that promote systems approaches to scientific problem solving through the development of educational modules that have provided positive STEM learning experiences for millions of students worldwide, and in each of the 50 states. A strong emphasis is placed on providing systems immuno-oncology internships and experiences to student populations traditionally under-represented in the STEM fields. The basic approach is to integrate these interns with ST-Analytics researchers to incorporate systems immuno-oncology concepts into two existing or in-development educational modules, entitled Systems Medicine Module 3 - Personalizing Disease Treatments, and Gaining Insight through Systems Thinking and Computational Modeling. While those modules are designed to meet Next Generation Science Standards (NGSS), the professional educators who are tasked with implementing those standards often do not have the proper background or supporting materials for the job. Thus, our outreach programs are also designed to provide that background and support. For example, we provide research-based, reality-driven professional development for more than 1,000 teachers and 80 district administrators annually, impacting over two-thirds of students in Washington. Thus, the potential impact of an ST-Analytics outreach program is large, and is achieved by leveraging extensive existing resources and relationships that extend throughout the state of WA and up and down the U.S. west coast. A program that solicits creative engagement from all participants within our proposed U54 program at all levels is described.