High School Student NeuroResearch Program (HSNRP)

摘要 亚利桑那大学(UA)高中生神经研究项目(HSNRP)介绍、培训和培育 亚利桑那州多样化的高中生和进步的本科生越来越多，大多数人代表不足- 在神经系统正常和异常的基础、翻译和临床研究中处于不利地位的少数民族， 神经疾病和中风，并鼓励先进的研究经验和健康/医疗/科学事业。 我们正在利用强大的基础设施、招聘策略、教师导师的参与和优秀的学员 我们长期受联邦政府资助的多学科贫困高中生、本科生、 以及医学生暑期研究计划和常年充实活动。14-16全日制8-12周 在接下来的5年里，每年暑期高中和4-6名本科实习生将获得更多 密切指导的神经研究(NR)经验。为了留住人才，精选的HSNRP学员将获得- 指出了更先进的天然橡胶。学员将被整合到一个创新的、以探究为基础的地中海夏季学院。 加州无知(SIMI)，将生物医学的知识和未知与特色的NR主题和导师交织在一起 “故事”，并通过一年四季的丰富活动保持势头。司米强调“翻译、翻译和 科学提问“，包括对医学语言的简要介绍、研讨会、实验室/领导力/ 多媒体技能工作坊和实践、临床相关性、社交网络和职业建议。一个问题-- Arium形成了一个可通过手机访问的培训和联网平台。在部门和专业中心内 以神经科学为重点的卓越，并由经验丰富的领导团队监督，学生研究将 包括体内、体外、原位、计算机和建模方法，用于神经生物学/疾病，包括帕金森氏症， 阿尔茨海默氏症，肌萎缩侧索硬化症，癫痫，头部创伤，脑积水，肌营养不良，疼痛/成瘾，分子精神病学， 脑发育，图谱，血脑屏障/神经保护，神经成像，神经基因组学，神经工程，深度 脑刺激、脑肿瘤、脑血管疾病、中风、神经健康差异和康复。基于我们的 ~29年的跟踪记录，并建立了接触亚利桑那州大量弱势学生的渠道，这反映在~650个Simi- 受过培训的高中生紧随其后的是基础/临床NR(本科/研究生/专业生物医学- 健康事业)管道，我们预计HSNRP将继续扩大不同的好奇的研究人员、医生的网络 和其他卫生专业人员；并通过社区参与提高“神经健康”素养。持续的短期-和 长期评估包括调查、数据库登记、后续行动和记录疗效的投资组合。

ABSTRACT The University of Arizona (UA) High School Student NeuroResearch Program (HSNRP) introduces, trains, and nurtures a growing pipeline of diverse Arizona high school students and progressing undergraduates, a majority of underrepresent- ed disadvantaged minorities in basic, translational, and clinical research on the normal and abnormal nervous system, neurological disorders, and stroke, and encourages advanced research experiences and health/medical/science careers. We are leveraging strong infrastructure, recruitment strategies, faculty mentor participation, and outstanding trainee productivity of our long-standing federally funded multidisciplinary disadvantaged high school student, undergraduate, and medical student summer research programs and year-round enrichment activities. Fourteen-16 full-time 8-12 week summer high school and 4-6 undergraduate trainees annually for the next 5 years will be offered an expanding menu of closely mentored NeuroResearch (NR) experiences. For retention in the pipeline, select HSNRP trainees will be reap- pointed for more advanced NR. Trainees will be integrated into an innovative, inquiry-based Summer Institute on Medi- cal Ignorance (SIMI) which interweaves biomedical Knowns and Unknowns with featured NR topics and mentor "stories" and sustains the momentum by enrichment activities year-round. SIMI emphasizes "translating translation and scientific questioning" and includes a brief Introduction to the language of medicine, seminars, laboratory/leadership/ multimedia skill workshops and practicums, clinical correlations, social networking, and career advising. A Question- arium forms a mobile phone accessible platform for training and networking. Within departments and specialized Centers of Excellence with Neuroscience emphasis and overseen by an experienced Leadership Team, student research will encompass in vivo, vitro, situ, silico, and modeling approaches to neurobiology/disorders including Parkinson's, Alzheimer's, ALS, epilepsy, head trauma, hydrocephalus, muscular dystrophy, pain/addiction, molecular psychiatry, brain development, mapping, blood-brain barrier/neuroprotection, neuroimaging, neurogenomics, neuroengineering, deep brain stimulation, brain tumors, cerebrovascular disease, stroke, neurohealth disparities, and rehabilitation. Based on our ~29-year track record and established access to large pools of disadvantaged Arizona students reflected in ~650 SIMI- trained high school students followed with many in basic/clinical NR (undergraduate/graduate/professional biomedical- health career) pipeline, we expect HSNRP to continue expanding the network of diverse curious researchers, physicians and other health professionals; and improve "neurohealth" literacy through community engagement. Ongoing short- and long-term evaluation includes surveys, database registry, follow-up, and portfolios to document efficacy.