Recyclable Catalyst Technology for Cross-Coupling Reactions at Manufacturing Scale

用钯（Pd）化合物催化的化学过程，以及基于诺贝尔奖获得者的方法，已经成为生产改善生活的药物和化学品的关键。这些流程支撑着全球每年仅制药业就价值超过100亿英镑的制造业。然而，Pd-催化剂的组分必须通过进一步昂贵和能量密集的处理从反应产物中回收。该项目将开发一种新的“捕获和释放”技术，该技术可以在反应产物被去除的同时捕获催化剂，然后以全功能活性形式释放催化剂以催化下一个反应。引入新的反应组分，允许另一个生产循环开始。这种新型半连续工艺将首先应用于制药和农业化学工业，然后开发用于其他加工工业，如新兴的塑料电子行业。

Chemical processes catalysed with Palladium (Pd) compounds, and based on Nobel-prize winning methods, have become essential for the production of life-enhancing pharmaceuticals & chemicals. These processes underpin global manufacturing worth more than £10billion each year for pharmaceuticals alone. However, the components of the Pd-catalyst must be recovered from the reaction products through further expensive and energy-intensive processing. This project will develop a new 'Catch & Release' technology which can catch the catalyst whilst reaction products are removed, and then release it in a fully-functional active form to catalyse the next reaction. New reaction components are introduced allowing another production cycle to begin. This novel semi-continuous process will be applied initially in the pharmaceutical & agrochemical industries and then developed for other process industries, such as the emerging plastic electronics sector.