2022 Conference: Clinical and Scientific Advances in Urinary Tract Infections

摘要 尿路感染是一个重大的社会经济负担，困扰着1.5亿患者 每年都有很多人死亡，其中大部分是健康的成年女性。抗生素使用率高， 治疗急性和反复发作的尿路感染导致了急剧增加， 由抗生素耐药性细菌引起的感染数量，包括超广谱β- 内酰胺生产菌株。有效抗生素治疗可用性的减少提高了 需要加快UTI研究的各个方面，正如我们的计划主题领域所概述的那样。 本次会议超越了基础科学研究成果的交流，并争取临床 研究结果的相关性，因为它们可以应用于临床实践以及使用临床 促进新的合作和实验方法的挑战。虽然健康的女性 代表了大多数接受尿路感染治疗的患者，我们将针对以前的 调查领域包括性别、年龄差异、易感因素和不良后遗症等。 此外，这次会议提供了跨专业的临床医生（如儿科，老年病， 产科、综合护理、急诊医学、泌尿科和肾脏科）的机会， 集思广益治疗方法，并沟通他们的研究需求 直接给研究人员，为未来的科学探索提供信息。通过全面关注 UTI的疾病，而不是任何一个研究或临床方法，讨论和合作 可以从长凳上走到床边作为预防和管理 UTI，我们也有一个培训使命，招募和支持早期职业研究人员和那些没有 传统上代表在医学和研究，因为他们过渡到下一代的 专家

ABSTRACT Urinary tract infections are a significant socioeconomic burden afflicting 150 million patients worldwide each year, most of whom are healthy adult women. The high rate of antibiotic usage to treat acute and recurrent episodes of urinary tract infection has led to a dramatic increase in the number of infections caused by antibiotic resistant bacteria including extended spectrum beta- lactam producing strains. The decrease in availability of efficacious antibiotic therapies has elevated the need to accelerate all aspects of UTI research as outlined in our programmatic topic areas. This conference goes beyond the exchange of basic science findings and strive for a clinical relevance of research findings as they can be applied to clinical practice as well as using clinical challenges to foster new collaborations and experimental approaches. Although healthy women represent the majority of patients treated for urinary tract infection, we will target previously under investigated areas such as sex and age differences, susceptibility factors and negative sequelae. Further, this conference provides clinicians across specialties (such as pediatrics, geriatrics, obstetrics, complex care, emergency medicine, urology, and nephrology) the opportunity to brainstorm treatment approaches with each other and to communicate their needs for research directly to researchers, informing future lines of scientific inquiry. By focusing holistically on the disease of UTI rather than on any one research or clinical approach, discussions and collaborations can cross from the bench to the bedside. As part of a long-term plan for preventing and managing UTI, we also have a training mission to recruit and support early career researchers and those not traditionally represented in medicine and research as they transition into the next generations of experts.