Therapeutic interventions for post-stroke rehabilitation

在美国，中风仍然是导致死亡和残疾的主要原因之一。该计划的主要目标 目前的建议是测试低温与全身振动联合治疗的疗效 使用老年大鼠卒中模型改善卒中后认知功能。主要有三种类型的 卒中：短暂性脑缺血发作、出血性卒中和急性缺血性卒中，后者构成 占总中风病例的87%。目前，治疗急性缺血性中风的唯一临床治疗方法是 溶栓(TPA)和机械血管内再通，这两种方法都仅限于 在少数患者中应用。认知能力下降是最重要的问题之一。 几乎三分之二的中风幸存者在中风后长达6年的时间内受到影响。因此，辨认小说 改善中风后认知的神经保护策略仍然是一个高度优先的问题。在动物模型中 中风(短暂性大脑中动脉闭塞-tMCAO)，行为研究提供了缺陷的证据 在空间、非空间和运动学习方面。在中年大鼠模型中，这些缺陷可以最小化 使用无创全身振动(WBV)疗法治疗中风。同样，长期的研究也是如此 来自我们实验室的研究表明，治疗性低温(TH)是一种有效的神经保护疗法 实验性脑缺血，在缺血级联的多个阶段有多种影响。这个 我们成功研究的翻译目标将是确定一种治疗中风的新方法 可以迅速转移到临床试验中进行测试的康复。

Stroke remains one of the leading causes of death and disability in the USA. The principal objective of the current proposal is to test the efficacy of combined therapeutic hypothermia with whole body vibration on post-stroke cognitive improvement using a model of stroke in aged rats. There are three main types of stroke: transient ischemic attack, hemorrhagic stroke and acute ischemic stroke, with the latter constituting 87% of total stroke cases. Currently, the only clinical therapies available for acute ischemic stroke are thrombolysis (tPA) and mechanical endovascular recanalization, both of which have only limited applications in a small number of patients. Cognitive decline is one of the most significant problems affecting almost two-thirds of stroke survivors for up to 6 years post-stroke. Therefore, identifying novel neuroprotective strategies to improve post-stroke cognition remains a high priority. In animal models of stroke (transient middle cerebral artery occlusion – tMCAO), behavioral studies yield evidence of deficits in spatial, non-spatial, and motor learning. These deficits can be minimized in middle-aged rat models of stroke with noninvasive whole body vibration (WBV) therapy. Likewise, long-standing research from our laboratory shows that therapeutic hypothermia (TH) is a potent neuroprotective therapy in experimental cerebral ischemia with multiple effects at several stages of the ischemic cascade. The translational goal of our successful study will be to identify a novel therapeutic approach for stroke rehabilitation that can be moved quickly to testing in clinical trials.