Administrative Core

项目摘要/摘要 目前的中心提案，题为“持续性血液感染的系统表观基因组学”，代表了 用协同方法了解导致危及生命的血流的宿主-病原体相互作用 不清楚适当治疗方法的感染。已经组建了一支极具创新性的专家团队，以 实施理想的系统生物学战略，以实现NIH/NIAID的优先事项。各式各样的专业知识， 技术和活动对于有效实现我们的目标是必要的。要有效地管理这一集成 研究计划，我们将实施我们成熟的管理网络核心(ANC)来与每个项目和 核心。因此，协同合作、研究效率和发现将得到提高。非国大的设计将负担得起 研究人员和中心组件之间的高效协调，包括项目1-3，以及我们的免疫组学 和表观遗传学(IEC)、生物信息学和数据管理(BDM)以及计算和预测建模(CPM)核心。 非国大与合作者和顾问的协调进一步增强了该中心的方案力量。这个 非国大将提供支持性基础设施，以确保实现中心的所有目标：1)管理项目 财政和人力资源；2)促进研究项目、核心和顾问的协调和整合； 3)通过监控基准指标和物流优化来确保质量改进；4)监督 补充研究项目的征集、审查、选择和监测；以及5)促进积极研究 一个公平、包容和多样化的环境。因此，非国大将支持整个中心通知、协调、 监督和推进所有研究目标的及时完成。

PROJECT SUMMARY/ABSTRACT The current Center proposal, entitled “Systems Epigenomics of Persistent Bloodstream Infection” represents a synergistic approach to understanding the host-pathogen interactions that result in life-threatening bloodstream infections that do not clear on appropriate therapy. A highly innovative and expert team has been assembled to implement a systems-biology strategy that is ideally aligned to achieve NIH / NIAID priorities. A diverse set of expertise, technologies and activities are necessary to efficiently reach our objectives. To effectively manage this integrated research program, we will implement our proven Administrative Network Core (ANC) to interact with each Project and Core. Thus, synergistic collaboration, research efficiency and discovery will be enhanced. The ANC design will afford highly efficient coordination among investigators and Center components, including Projects 1–3, and our Immunomics & Epigenetics (IEC), Bionformatics & Data Management (BDM) and Computational & Predictive Modeling (CPM) Cores. Coordination with Collaborators and Consultants by the ANC further amplifies the programmatic strengths of the Center. The ANC will provide a supportive infrastructure to ensure accomplishment of all Center goals: 1) managing the project financial and personnel resources; 2) facilitating coordination and integration of research Projects, Cores and Advisors; 3) ensuring quality improvement by monitoring of benchmark metrics and logistical optimization; 4) overseeing the solicitation, review, selection and monitoring of Supplemental Research Projects; and 5) promote a positive research environment that is equitable, inclusive and diverse. Thus, the ANC will support the overall Center to inform, coordinate, monitor and advance timely completion of all research goals.