Developing wearable OPM-MEG to assess brain function in mother-infant dyads during social interactions

项目摘要 拟议的工作将适应目前的可穿戴，光泵磁力计为基础的 脑磁图（opmMEG）用于婴儿，然后将进一步调整这些协议， 在自然主义的社会互动过程中，同时记录母婴二人组的大脑活动。虽然这两 脑电图（EEG）和功能性磁共振成像（fMRI）已被用于评估 婴儿的大脑功能，脑电图甚至被用来同时评估母亲和婴儿的二元大脑 在自然交互过程中发挥作用，它们各自具有可穿戴opmMEG解决的局限性。 EEG和fMRI都允许高时间，毫秒，分辨率;然而，EEG对源提出了挑战。 本地化虽然fMRI解决了EEG的源定位问题，但它不允许相同的 自然主义的社会范式，如脑电图，也是响亮和昂贵的。OpmMEG是非侵入性的，安静的， 提供了高时间分辨率和精确的源定位。可在室内使用OPM MEG传感器是一种高温度传感器，不像其他MEG传感器必须使用昂贵的冷冻剂进行冷却。OPM也很小 重量轻，使它们适合用于可穿戴头盔，即使在范式中也可以使用 包括参与者运动。opmMEG的所有这些特性使其成为适应性的理想候选者 用于婴儿，以及进一步用于自然相互作用的母婴对。评估大脑功能的能力 同时在一个母婴二元体中代表了一个前所未有的机会， 典型的发展，这是能够识别临床相关的大脑功能模式的关键， 后来出现的精神病理学一旦拟议的工作完成，我们将开发 优化的协议，并首次在婴儿中收集opmMEG数据，以及首次 在自然的、身体接触的、社交的过程中同时收集的母婴opmMEG 交互.该提案所代表的创新对于推动婴儿成像领域的发展至关重要 垂直地提高我们对神经发育的理解，使用存在于 发育上独特的和形成性的母婴二分体。

PROJECT SUMMARY The proposed work will adapt current wearable, optically pumped magnetometer-based magnetoencephalography (opmMEG) for use in infants, and will then further adapt these protocols for simultaneous recording of brain activity in mother-infant dyads during naturalistic social interactions. While both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) have been used to assess brain function in infants, and EEG has even been used to simultaneously assess mother-infant dyad brain function during naturalistic interactions, they each have limitations that are addressed by wearable opmMEG. Both EEG and fMRI allow for high temporal, millisecond, resolution; however, EEG poses challenges for source localization. Although fMRI addresses the source localization issues of EEG, it does not allow for the same naturalistic social paradigms as EEG, and is also loud and expensive. OpmMEG is non-invasive, quiet, and provides both high temporal resolution and accurate source localization. OPMs can be used at room temperature, unlike other MEG sensors that must be cooled using expensive cryogens. OPMs are also small and lightweight, making them amenable to use in wearable helmets, which can be used even during paradigms that include participant motion. All of these characteristics of opmMEG make it an ideal candidate for adaptation for use in infants, and further, use in naturally interacting mother-infant dyads. The ability to assess brain function simultaneously within a mother-infant dyad represents an unprecedented opportunity to gain knowledge about typical development, which is key to being able to recognize clinically relevant patterns of brain function indicative of later emerging psychopathology. Once the proposed work is completed, we will have developed optimized protocols, and the first-ever opmMEG data collected in an infant, as well as the first ever simultaneous mother-infant opmMEG collected during naturalistic, physically-touching, social interactions. The innovations represented by this proposal are paramount to moving the field of infant imaging vertically to improve our understanding of neurodevelopment using salient social interactions that exist within the developmentally unique and formative mother-infant dyad.