Research Core

项目摘要/摘要：生物信息学和生物统计学(BBC)研究核心 癌症健康公平促进中心(CEPCHE)将提供集中管理、支持、 为先进的调查人员提供专门的技术服务和评估，并创造一个持续的综合 基础研究开发和支持中心。为了实现这一目标，CEPCHE将建立一个更多- 需要生物信息学和生物统计学核心(BBC)来加强和改进波多黎各大学 RICO在癌症研究方面的基础设施有限。BBC的目标是成为一个专家枢纽， 为CEPCHE的研究项目负责人(RPL)和流水线提供生物信息学和生物统计学 早期研究人员投资于癌症研究。为了实现这一目标，英国广播公司成立了 具体目标如下：(一) 实施、数据分析、 为研究设计方法提供生物统计学援助和支持， 和生物医学数据的解释；(2)提供生物信息学支持 预测分析(人工智能和机器学习)和计算支持(软件工具和 应用编程接口或API)；(3)建立适合大数据的计算基础设施 用于收集、整理、批注、管理和存储主要和 次级数据库；以及(4)建立和加强BBC的工作关系和培训组合 与其他创意机构合作。此外，BBC将支持和培训RPL和其他有前途的年轻人 调查人员在数据处理、管理和分析方面阐述了CEPCHE的主题。英国广播公司将 在创建、收集和维护共享数据存储库方面发挥主导作用，以扩展 普遍定期审议教职员工可以立即访问这些多个数据集和资源。预计英国广播公司将 为CEPCHE的RPL提供坚实的基础设施，以加快他们的研究，及时发布结果 在高影响力的同行评议期刊上发表，并在三年内准备和提交有竞争力的R型提案 关于CePChe的启动。 OMB编号0925-0001/0002(批准的第03/2020版至2023年2月28日)续页格式页

PROJECT SUMMARY/ABSTRACT: BIOINFORMATICS AND BIOSTATISTICS (BBC) RESEARCH CORE The Center for the Promotion of Cancer Health Equity (CePCHE) is to provide centralized management, support, specialized technical services, and evaluation for advancing investigators, and creating a sustained integrated basic research development and support center. To accomplish this aim, the CePCHE will establish a much- needed Bioinformatics and Biostatistics Core (BBC) to strengthen and improve the University of Puerto Rico’s (UPR) limited infrastructure in cancer research. The goal of the BBC is to serve as an expert hub to address bioinformatics and biostatistics for the CePCHE’s Research Projects Leaders (RPLs) as well as pipeline and early-stage investigators invested in cancer research. To accomplish this goal, the BBC has established the following specific aims: (1) To implementation, data analysis, provide biostatistical assistance and support for study design methodology, and interpretation of biomedical data; (2) Provide bioinformatics support in predictive analytics (artificial intelligence and machine learning), and computational support (software tools and application programming interfaces or APIs); (3) Establish a computational infrastructure suitable for big-data analyses, and data repository for data collection, curation, annotation, management, and storage of primary and secondary databases; and (4) Establish and strengthen working relationships and a training portfolio of the BBC with other IDeA institutions. Additionally, the BBC will support and train RPLs and other promising junior investigators addressing the CePCHE’s theme in data processing, management, and analysis. The BBC will play a leading role in the creation, collection, and maintenance of a shared Data Repository to expand the immediate access of UPR faculty to these multiple data sets and resources. It is expected that the BBC will provide a solid infrastructure for CePCHE’s RPLs to expedite their research, publish results in a timely manner in high impact peer-reviewed journals, and prepare and submit competitive R-type proposals within three years of initiation of the CePCHE. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page