Modified plant saponins for the control of liver fluke in livestock

牛和羊的肝吸虫代表了一个日益严重的经济问题，特别是因为对可用药物产生耐药性，以及代表了一个严重的动物福利问题。该项目将开发一种基于自然的替代处理方法，使用一种散装化学品，这种化学品可以从一种普通的非食品植物中大量分离出来，目前在英国这种植物很少使用，通常通过燃烧来控制。这种植物材料本身已知对吸虫有效，将通过简单的过程转化为单一的化学实体，然后进行修改以优化其活性。这将使用一种高度专业化的方法来确定，在体外测量对吸虫的许多个体影响，并在小型体内研究期间进行。该联合体将编制一份完整的产品档案，包括材料供应、产品配方、功效和输送系统、进入市场的途径，以及对控制疾病的潜在效益的分析，并计算其成本;预计该项目组合将导致联合体伙伴直接进入全面产品注册过程，或许可输出的联合体，以便这样的过程可以开始。

Liver fluke in cattle and sheep represents an increasing economic problem, particularly because of developing resistance to available drugs, as well as representing a serious animal welfare issue. This project will develop a nature based alternative treatment by using a bulk chemical that can be isolated in large quantities from a common non-food plant which is currently little used in the UK and often controlled by burning. The plant material, which itself is know to be actve against fluke, will be converted into a single chemical entity by simple processes and then modified to optimise its activity. This will be determined using a highly specialised approach measuring in vitro many individual effects on the fluke, and during small in vivo studies. The consortium will develop and cost a complete product dossier, including material supply, product formulation, efficacy and delivery systems, a route to market,and an analysis of the potential benefits in controlling disease; it is expected that this project portfolio will either lead to a consortium partner moving directly to the process of full product registration , or to the consortium licencing the outputs so that such a process could begin.