New antiparasitics to protect Australian livestock

目前迫切需要新的抗寄生虫药来治疗多重耐药家畜感染。该项目旨在探索严重感染的绵羊粪便和牧场微生物组中存在的细菌和真菌，用环境线索（包括相关寄生虫）挑战它们，以刺激隐藏在其基因组深处的防御化学物质的产生。通过高通量分析培养、分子网络以及化学和生物分析的综合管道，预期的结果包括探索和利用隐藏在微生物基因组中的有价值化学物质的能力增强，从而发现新的天然抗寄生虫药物类别，以保护牲畜。

There is an urgent need for new antiparasitics to treat multi-drug resistant livestock infections. This project aims to explore the bacteria and fungi present in the microbiomes of heavily infected sheep faeces and pastures, challenging them with environmental cues, including those from associated parasites, to stimulate production of defensive chemicals hidden deep within their genomes. Enabled by an integrated pipeline of high throughput analytical cultivation, molecular networking, and chemical and biological analyses, expected outcomes include an enhanced ability to explore and exploit valuable chemistry hidden within microbial genomes, leading to the discovery of new classes of natural antiparasitic to safeguard livestock.