ANTIPROLIFERATIVE EFFECT OF WILD-TYPE P53

编码核磷蛋白P53的基因是一个常见的靶点 在各种各样的人类肿瘤中发生突变。野生型P53蛋白 编码正常的P53基因显示出强大的生长抑制作用 蛋白质的突变形式所不具备的活性。近期 研究表明，P53蛋白既可以发挥积极作用，也可以发挥消极作用。 对基因表达的影响。野生型P53蛋白的作用能力 调节基因表达与其生长抑制有关 活动。我们之前已经证明了野生型基因的过度表达- P53蛋白表达下调与人卵巢癌的关系 编码增殖细胞核的内源性生长调节基因 P53反应元件的抗原(PncA)、B-识别和 与P53协同作用的核蛋白成分的特性 在调控其中两个基因的表达中；增殖细胞核抗原和DNA 聚合酶阿尔法。从这项研究中获得的信息将增加到 对P53基因调控机制的认识 表情。

The gene encoding the nuclear phosphoprotein p53 is a frequent target of mutation in a wide variety of human tumors. The wild-type p53 protein encoded for the normal p53 gene exhibits a potent growth-suppressing activity which is absent from mutant forms of the protein. Recent studies have shown that p53 proteins can exert both positive and negative effects on gene expression. The ability of the wild-type p53 protein to modulate gene expression has been linked to its growth-suppressing activity. We have previously demonstrated that overexpression of wild- type p53 protein is correlated with down-regulation in the expression of the endogenous growth-regulated genes encoding proliferating cell nuclear antigen (PNCA), B-identification of p53-responsive elements and the characterization of nuclear protein components that collaborate with p53 in modulating the expression of two of these genes; PCNA an DNA polymerase alpha. Information obtained from this study will increase out understanding of the mechanisms of P53-mediated regulation of gene expression.