CELL AND MOLECULAR BIOLOGY OF ACUTE LEUKEMIA
CELL AND MOLECULAR BIOLOGY OF ACUTE LEUKEMIA
批准号:
2100705
负责人:
HARVEY D PREISLER
金额:
$31.81万
依托单位国家:
美国
项目类别:
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-08-01 至 1997-05-31
关键词:
acute leukemia acute myelogenous leukemia antileukemic agent biological response modifiers cell growth regulation cellular oncology colony stimulating factor combination cancer therapy human subject human therapy evaluation interferons molecular oncology neoplasm /cancer genetics neoplasm /cancer immunotherapy nutrition related tag protooncogene retinoate vitamin therapy
中文摘要
这笔赠款将解决以下几个方面的潜在影响:
体内对白血病细胞的生物活性物质。白血病细胞将是
在服用这些药物之前和之后获得的结果以及
这些药物对白血病细胞周期时间分布的影响
我们将探索单个患者体内的细胞。这些因素的影响
影响原癌基因fms、myb、IL1β和myc表达的药物
也将被研究。首先,我们将研究维甲酸的作用
酸/干扰素和重组人粒细胞集落刺激因子。这些研究将扩展到其他药物
一旦这些初步研究完成。并行评价
体外生物活性物质将被进行,以便在体外预测
可以开发出检测方法。
英文摘要
This grant will address several aspects of the potential affects of
bioactive agents on leukemia cells in vivo. Leukemia cells will be
obtained before and after administration of these agents and the effects of
these agents on the distribution of cell cycle times amongst the leukemia
cells within individual patients will be explored. The effects of these
agents on the expression of the protooncogenes fms, myb, IL1beta and myc
will be studied as well. Initially, we will study the effects of retinoic
acid/interferon and rhGM-CSF. The studies will be extended to other agents
once these initial studies are completed. Parallel evaluation of the
bioactive agents in vitro will be conducted so that predictive in vitro
assays can be developed.
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会议论文
MDS EVOLUTION TO AML--MOLECULAR BIOLOGY AND CYTOKINES
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批准号:6659206
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项目类别:
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资助金额:$31.28万
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财政年份:2002
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负责人:HARVEY D PREISLER
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依托单位:
CORE--MOLECULAR BIOLOGY
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批准号:6659200
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项目类别:
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资助金额:$31.28万
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财政年份:2002
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负责人:HARVEY D PREISLER
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依托单位:
MDS EVOLUTION TO AML--MOLECULAR BIOLOGY AND CYTOKINES
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批准号:6459014
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项目类别:
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资助金额:$31.28万
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财政年份:2001
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负责人:HARVEY D PREISLER
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依托单位:
CORE--MOLECULAR BIOLOGY
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批准号:6459008
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项目类别:
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资助金额:$31.28万
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财政年份:2001
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负责人:HARVEY D PREISLER
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依托单位:
CORE--MOLECULAR BIOLOGY
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批准号:6348986
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项目类别:
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资助金额:$24.36万
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财政年份:2000
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负责人:HARVEY D PREISLER
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依托单位:
MDS EVOLUTION TO AML--MOLECULAR BIOLOGY AND CYTOKINES
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批准号:6348992
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项目类别:
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资助金额:$24.36万
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财政年份:2000
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负责人:HARVEY D PREISLER
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依托单位:
MDS EVOLUTION TO AML--MOLECULAR BIOLOGY AND CYTOKINES
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批准号:6103427
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项目类别:
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资助金额:$24.36万
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财政年份:1999
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负责人:HARVEY D PREISLER
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依托单位:
CORE--MOLECULAR BIOLOGY
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批准号:6103430
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项目类别:
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资助金额:$24.36万
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财政年份:1999
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负责人:HARVEY D PREISLER
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依托单位:
CORE--MOLECULAR BIOLOGY
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批准号:6269880
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项目类别:
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资助金额:$23.81万
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财政年份:1998
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负责人:HARVEY D PREISLER
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依托单位:
MDS EVOLUTION TO AML--MOLECULAR BIOLOGY AND CYTOKINES
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批准号:6269877
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项目类别:
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资助金额:$23.81万
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财政年份:1998
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负责人:HARVEY D PREISLER
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依托单位:
SECONDARY HEMATOLOGIC DISORDERS--GENESIS AND TREATMENT
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批准号:2406364
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项目类别:
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资助金额:$187.88万
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财政年份:1997
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负责人:HARVEY D PREISLER
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依托单位:
SECONDARY HEMATOLOGIC DISORDERS--GENESIS AND TREATMENT
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批准号:6172689
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项目类别:
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资助金额:$200.31万
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财政年份:1997
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负责人:HARVEY D PREISLER
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依托单位:
SECONDARY HEMATOLOGIC DISORDERS--GENESIS AND TREATMENT
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批准号:2712894
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项目类别:
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资助金额:$190.47万
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财政年份:1997
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负责人:HARVEY D PREISLER
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依托单位:
SECONDARY HEMATOLOGIC DISORDERS--GENESIS AND TREATMENT
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批准号:2896190
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项目类别:
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资助金额:$194.87万
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财政年份:1997
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负责人:HARVEY D PREISLER
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依托单位:
MDS EVOLUTION TO AML--MOLECULAR BIOLOGY AND CYTOKINES
-
批准号:6237819
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项目类别:
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资助金额:$23.49万
-
财政年份:1997
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负责人:HARVEY D PREISLER
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依托单位:
CORE--MOLECULAR BIOLOGY
-
批准号:6237822
-
项目类别:
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资助金额:$23.49万
-
财政年份:1997
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负责人:HARVEY D PREISLER
-
依托单位:
STUDIES OF THE CELL & MOLECULAR BIOLOGY OF ACUTE LEUKEMI
-
批准号:3203868
-
项目类别:
-
资助金额:$11.07万
-
财政年份:1992
-
负责人:HARVEY D PREISLER
-
依托单位:
STUDIES OF THE CELL & MOLECULAR BIOLOGY OF ACTE LEUKEMIA
-
批准号:3203870
-
项目类别:
-
资助金额:$17.65万
-
财政年份:1992
-
负责人:HARVEY D PREISLER
-
依托单位:
CELL AND MOLECULAR BIOLOGY OF ACUTE LEUKEMIA
-
批准号:2100704
-
项目类别:
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资助金额:$30.3万
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财政年份:1992
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负责人:HARVEY D PREISLER
-
依托单位:
STUDIES OF THE CELL & MOLECULAR BIOLOGY OF ACTE LEUKEMIA
-
批准号:3203869
-
项目类别:
-
资助金额:$30.15万
-
财政年份:1992
-
负责人:HARVEY D PREISLER
-
依托单位:
海外基金