MOLECULAR CYTOGENETIC ANALYSIS OF HUMAN CHROMOSOMES

该项目的目标是将诊断探头开发与 正在编制的物理地图位置以及遗传基因座 基因组计划。公认和接受的DNA标记将作为 基因作图者的有用工具以及有价值的诊断试剂 临床细胞遗传学家。开发一个组织良好的 其物理和遗传位置由基因组识别的一组探针 项目包括： *这组探针可以用作一组要使用的参考标记 在先前未定位的基因的杂交作图中。 *将诊断探针集整合到基因组数据库中将 促进对试剂的理解并加快其使用速度。 *基因组社区产生的新信息可以很容易地 集成到探头集合中。 该项目的第二个目标是继续开发荧光 使我们能够更容易地检测到探测器是 发展起来的。

The goals of the project are to couple diagnostic probe development to physical map locations as well as genetic loci that are being compiled by the genome project. Recognized and accepted DNA markers would serve as useful tools for gene mappers as well as valuable diagnostic reagents for clinical cytogeneticists. The advantages to developing a well organized set of probes whose physical and genetic loci are recognized by the genome project are: * This set of probes could serve as a set of reference markers to be used in hybridization mapping of previously unmapped genes. * The integration of diagnostic probe sets into the genome database will facilitate the understanding of the reagents and expedite their use. * New information generated from the genome community can readily be integrated into the probe set. The second goal of this project is to continue to develop fluorescent chemistries that will enable us to more readily detect the probes to be developed.