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Reconstructing Somatic Chromosomes

Reconstructing Somatic Chromosomes
重建体细胞染色体
批准号：
10772559
负责人：
SHOUKHRAT M MITALIPOV
金额：
$65.99万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
未结题
起止时间：
2023-09-26 至 2028-06-30
来源：
https://reporter.nih.gov/project-details/10772559
关键词：
Base SequenceBiologicalCell CycleCell NucleusCell divisionCellsCharacteristicsChromatidsChromatinChromosome PairingChromosomesCytoplasmDNA Double Strand BreakDNA biosynthesisDevelopmentDiploid CellsDiploidyDiseaseElderlyEmbryoEmbryo ResearchEmbryo TransferEpigenetic ProcessEventFertilizationFrequenciesFutureG1 ArrestGametogenesisGenerationsGeneticGenetic RecombinationGenetic TranscriptionGenomeGerm CellsGoalsHaploidyHomologous GeneHumanHybrid CellsIn VitroInbred Strains MiceInfertilityInterphaseMammalsMeiosisMetaphaseMusOocytesPathway interactionsPatientsPloidiesPre-implantation Embryo DevelopmentPrimatesProcessProductionResearchRoleSkinSomatic CellTherapeuticTotipotencyTotipotentTransplantationTriploidydaughter celldirected differentiationeggembryonic stem cellimprintinduced pluripotent stem cellinfertility treatmentinsightmouse modelnoveloffspringprematureprogramsreproductivesegregationsomatic cell nuclear transfersperm cellsuccesstherapy developmentzygote

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Project Summary: Somatic cell nuclear transfer (SCNT) replaces haploid meiotic chromosomes in metaphase (MII)-arrested oocytes with diploid interphase chromatin from somatic cells. Such SCNT oocytes are diploid and are not suitable for fertilization due to triploidy. However, our preliminary studies indicate that SCNT oocytes are capable of forming premature meiotic spindles consisting of paired single-chromatid chromosomes and subsequent activation or fertilization can induce segregation of somatic chromosomes into a pseudo polar body. Our research will determine if somatic homolog pairing and recombination in mouse SCNT oocytes can be induced by DNA double strand breaks and develop future therapeutic approaches for infertility treatments.
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    OREGON HEALTH & SCIENCE UNIVERSITY
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