Robust purification of a hight value lipopeptide

EnzBond创造了一条通往高价值脂肽药物产品的新途径，由于产品非常粘，在最后一步纯化和处理中已经达到瓶颈。产品的“粘性”是一种大分子结构胶束形成的结果，用我们目前的方法很难研究。最终的结果是严重的下游问题，如塔堵塞和多轮净化由于杂质被困。在与国家物理实验室的合作中，将更好地理解胶束的物理性质，并开发新的纯化方法。在项目结束时，EnzBond将有一个创新的连续过程来生产超纯的脂肽，而不会出现已知的问题。

EnzBond has created a novel route to a high value lipid-peptide pharmaceutical product and a bottle neck has been reached in the final step purification and handling as the product is very sticky. The "stickiness" of the product is a result of a macro-molecular structure, micelle, forming which is difficult to study using our current methods. The end result is significant downstream issues such as column blockage and multiple rounds of purification due to impurities being trapped. In collaboration with NPL, the physics of the micelle will be better understood and novel purification methods will be developed. At the end of the project EnzBond will have an innovative continuous process to produce a ultra-pure lipopeptide without the known issues arising.