LONGITUDINAL ANALYSIS OF ASR FOLLOWING PRENATAL COCAINE

产前接触可卡因已被证明会产生 人类和实验动物的神经行为变化。在 矛盾的是，研究结果表明，影响是最小的， 短暂的在这种差异的基础上， 在发育的关键时期，受试者的年龄 评估，并选择有效的神经行为措施。 声音惊吓反应（ASR）被广泛认为是一种衡量 中枢神经系统功能由于ASR的感觉和运动成分对 有毒物质的影响，因为反应性能受到影响， 通过增龄，选择ASR作为纵向的功能指标， 产前可卡因的影响客观、细粒度的ASR分析 被认为是能够区分行为变化， 与产前药物暴露有关的长期变化导致的正常衰老。 年龄 * 预期可卡因暴露大鼠会出现治疗相互作用。 妊娠大鼠组将经口给予25或50 mg/kg 从妊娠第6天到第20天每天服用可卡因。ASR将在2，8， 14、20月龄的后代组。受试者的回答将被转换 转换成电信号，数字化，并通过计算机处理。在 除了传统的措施，全面的全波分析 将被执行。隔离主题和系统组件的技术 使用。

Prenatal exposure to cocaine has been demonstrated to produce neurobehavioral changes in humans and laboratory animals. In contradiction are findings that suggest the effects are minimal and transient. At the base of this discrepancy are issues such as CNS exposure during critical periods of development, the age of subject assessment, and the selection of valid neurobehavioral measures. The acoustic startle response (ASR) is widely regarded as a measure of CNS function. Since sensory and motor components of ASR are sensitive to the effects of toxicants, and because response performance is affected by aging, ASR was selected as a functional index of the longitudinal effects of prenatal cocaine. An objective and fine-grained ASR analysis is regarded as capable of differentiating behavioral changes due to normal aging from long-term changes related to prenatal drug exposures. Age * Treatment interactions are anticipated for cocaine-exposed rats. Groups of pregnant rats will be orally administered 25 or 50 mg/kg cocaine daily from gestation days 6 to 20. ASR will be examined in 2, 8, 14, & 20 month-old offspring groups. Subject responses will be converted to an electrical signal, digitized, and processed via computer. In addition to traditional measures, a comprehensive whole wave analysis will be performed. Techniques to isolate subject and system components are use.