MICRODROP DYE DISPENSER FOR SURGICAL LASERS

这项提议涉及到一种高级激光手术工具的开发。 我们发现，当组织经过预处理时，激光消融效果会增强。 带有微滴的染料，名义上直径为50微米。染料的使用 将激光能量耦合到组织有两个优点。(I)能源 吸收是由染料的光学特性决定的(不是 组织)，因此新一代廉价、紧凑的半导体激光器可以 被带去执行外科手术任务。(Ii)因为外科医生可以对组织进行“涂色” 通过在每次激光发射之前短暂地爆发染料，他们获得了一种新的 对激光对组织的影响进行交互控制的维度。 我们提出的仪器结合了一种微型固态流体 基于喷墨打印技术的微型分配器和激光光纤 在一个纤细的内窥镜仪器里。我们将进行的研究的第一阶段(一) 评估各种染料，包括亲脂性、“粘性”的外科用染料 使用，(Ii)探索激光与组织相互作用的基本原理 (热扩散、光声效应)通过使用染料和 (Iii)评估临床疗效(消融效率vRS组织 损害)的选定激光-染料组合。在第二阶段，我们预计 样机组装和临床前、活体测试。

This proposal concerns the development of a superior laser surgical tool. We have found that laser ablation is enhanced when tissue are pretreated with microdrops of dye, nominally 50um in diameter. The use of dye to couple the laser energy to the tissue has two advantages. (i) Energy absorption is governed by the optical characteristics of the dye (not the tissue), thus the new-generation of cheap, compact diode laser can be harnessed to surgical task. (ii)Because surgeons can "paint" the tissue with brief burst of dye prior to each laser shot, they gain a new dimension of interactive control over their laser's impact on tissue. Our proposed instrument combines a miniature, solid-state fluid microdispenser, based on ink jet printing technology, and a laser fiber in a slim, endoscopic instrument. I Phase I of the research we will (i) evaluate various dyes, including lipophilic, "sticky" dyes for surgical use, (ii) explore how the fundamentals of laser-tissue interaction (thermal diffusion, photoacoustic effects) are modified b use of dyes and (iii) assess the clinical efficacy (ablation efficiency vrs tissue damage) of selected laser-dye combinations. In Phase II we anticipate assembly of prototype instruments and pre-clinical, in vivo testing.