DIETARY PATTERNS AND BLOOD PRESSURE

该提案是协调中心（CC）对RFA膳食营养建议的回应。 模式和血压。 CC将位于Kaiser 永久健康研究中心（CHR），咨询 俄勒冈州健康科学大学和一个食品成分分析仪 弗吉尼亚理工学院的分析。 检察官和调查人员 在开展临床试验、高血压、 研究、喂养研究、食物分析以及处理和分析 大型数据库。 申请人也有协调经验 中心，而该中心的结构是为了最佳地支持这样一个 机构。 我们建议进行一次三臂试验，在此之前进行为期4周的磨合，“典型的 美国”饮食。“典型的美国”饮食将继续作为 在研究的干预阶段控制饮食。 两 比较将涉及高矿物质（K，Mg，Ca）和低脂肪高纤维 节食。 我们还建议不易腐烂的食物应在中央 厨房、冷冻并运送到临床中心，以最大限度地提高均匀性 饮食和最大限度地减少质量控制问题。 最后，我们提出了一个 利用高血压降低血压变化的机制 试验受试者的每日访视。 设计方案具有相当大的 检测血压变化的能力比模型更强 在RFA中建议。 申请人的专业知识和经验相结合， 联合国及其附属科学家是担任 协调中心。

This proposal is a Coordinating Center (CC) response to the RFA on Dietary Patterns and Blood Pressure. The CC will be located at the Kaiser Permanente Center for Health Research (CHR), with consultation from the Oregon Health Sciences University and a subcontract for food composition analyses to Virginia Polytechnic Institute. The CHR and the investigators have extensive experience in the conduct of clinical trials, hypertension research, feeding studies, food analysis, and the handling and analysis of large databases. The applicants also have experience as a coordinating center, and the CHR is structured to optimally support such an institution. We propose a three-armed trial, preceded by a 4-week run-in, "typical American" diet. The "typical American" diet would be continued as the control diet during the intervention phase of the study. The two comparisons would involve high mineral (K, Mg, Ca) and low fat-high fiber diets. We also propose that non-perishable foods be prepared in a central kitchen, frozen, and shipped to clinical centers to maximize uniformity of diets and minimize quality control problems. Finally, we propose a mechanism for reducing variance in blood pressure by taking advantage of the daily visits of trial subjects. The proposed design has considerably greater power for detecting changes in blood pressure than does the model suggested in the RFA. The combination of expertise and experience of the applicants makes the CHR and its affiliated scientists an ideal group for serving as coordinating center for this trial.