Nano-reactors: Protein cages as reusable scaffolds for designer enzymes

该项目旨在开发来自病毒外壳的坚固蛋白笼，以包含热稳定的P450酶，用作化学工业中的专用蛋白质生物催化剂。可再生生物塑料的一种有价值的化学前体将通过酶从种子油中生产，减少化石燃料的使用。这种合成生物学方法结合了生物技术、纳米技术和蛋白质工程，建立了一个基于植物的生物技术平台，利用酶作为催化剂来制造高价值分子。该项目旨在展示如何在设计师纳米环境中设计清洁，可持续的化学。这将使合成工艺更具可持续性，并加强澳大利亚的先进化学制造业。

This project aims to develop robust protein cages derived from the coats of viruses to contain heat-stable P450 enzymes, for use as specialised protein bio-catalysts in chemical industries. A valuable chemical precursor of renewable bio-plastics will be produced from seed oils by enzymes, reducing the use of fossil fuels. This synthetic biology approach combines biotechnology, nanotechnology and protein engineering to establish a plant-based platform biotechnology for using enzymes as catalysts to make high-value molecules. The project aims to show how to engineer clean, sustainable chemistry in designer nano-environments. This should make synthetic processes more sustainable and enhance advanced chemical manufacturing in Australia.