Sphingosine-1-phosphate receptor 5: a novel regulator of T cell immunity

T细胞提供了对抗感染和癌症的关键免疫保护。然而，调节这些免疫细胞的途径尚未完全了解。T细胞表达一种名为S1P5的分子，该分子在这些细胞中具有未知的功能。在这个提议中，我们揭示了新的证据，表明这种分子是T细胞行为的一种不受重视的关键调节因子。利用最先进的技术和新的遗传工具，该项目旨在发现S1P5参与免疫反应，并确定如何控制S1P5以增强保护性T细胞免疫。预期的结果是产生对免疫反应的调节具有重要意义的基本新知识。

T cells provide critical immune protection against infection and cancer. However, the pathways that regulate these immune cells are not fully understood. T cells express a molecule called S1P5 that has an unknown function in these cells. In this proposal, we reveal new evidence that this molecule is an unappreciated and crucial regulator of T cell behaviour. Using state-of-the-art techniques and novel genetic tools, this project aims to discover the involvement of S1P5 in the immune response, and determine how S1P5 can be controlled to enhance protective T cell immunity. The expected outcomes are to generate fundamental new knowledge that will have significance for regulation of the immune response.