AUDITORY TECTO-THALAMIC PATHWAYS INFORMATION PROCESSING

声学行为依赖于由多个路径传递的信息 从下丘投射到内侧膝状体，以及 然后到达听觉皮质。这项研究的长期目标是 评估这些听觉通路中的信息处理。这个 拟议的研究将具体检查预测的组织 从下丘到内侧膝状体， 内侧膝状体神经元的生理特性。特价 将把注意力放在声音的连接和机制上 声学信息的本地化与集成 频段。 双耳反应和声音定位提示被组织在 胡子蝙蝠下丘的等频表现。 下丘的上行投射将通过 在生理定义的区域放置顺行示踪剂沉积物 通过它们对双耳输入和声音频率的反应。两条顺行路线 示踪剂，放置在不同的双耳分区，将用于评估 下层双耳分区的收敛程度 丘脑。然后，单单位反应和多单位反应的生理学研究 在内侧膝状体将评估生理和功能 双耳反应的组织。这些研究将确定 关于双耳提示的信息是从下级传达的 丘脑至内侧膝状体，以及这一信息是如何 由内侧膝状体内的神经元处理。它还将进一步 为更深入地理解听觉皮质是如何 处理和表示与声音本地化相关的双耳提示，以及 这就是这一重要的声学行为的基础。 分析声音位置和其他声学特征的Neuml机制可以 依赖于跨不同等频率的信息整合 申述。频率特定输入的汇聚 下丘到内侧膝状体的细分将是 通过将两种顺行示踪剂放置在不同的位置进行研究 下丘的频数表示。生理学研究 内侧膝状体中的单个单位然后将确认该组织 会聚的输入，并识别这样的 神经元。这些研究将提供有关综合技术的信息 分析声音定位和其他声学特征的机制 在听觉系统内。

Acoustic behavior relies on information conveyed by multiple pathways projecting from the inferior colliculus to the medial geniculate body, and then to the auditory cortex. The long term goal of this research is to evaluate information processing within these auditory pathways. The proposed research will specifically examine the organization of projections from the inferior colliculus to the medial geniculate body, and the physiological properties of neurons in the medial geniculate. Special attention will be placed on connections and mechanisms involved in sound localization and in the integration of acoustic information from different frequency bands. Binaural responses and sound localization cues are organized within isofrequency representations of the mustached bat's inferior colliculus. The ascending projections of the inferior colliculus will be studied by placing deposits of anterograde tracer in regions defined physiologically by their responses to binaural input and sound frequency. Two anterograde tracers, placed in dfferent binaural subdivisions, will be used to evaluate the degree of convergent input from binaural subdivisions in the inferior colliculus. Then, physiological studies of single and multi-unit responses in the medial geniculate will evaluate the physiology and functional organization of binaural responses. These studies will establish what information regarding binaural cues is conveyed from the inferior colliculus to the medial geniculate body, and how this information is processed by neurons within the medial geniculate. It will furthermore provide the basis for a deeper understanding of how the auditory cortex processes and represents binaural cues related to sound localization, and thus underlies this important acoustic behavior. Neuml mechanisms analyzing sound location and other acoustic features may depend upon the integration of information across different isofrequency representations. The convergence of frequency-specific input from the inferior colliculus onto subdivisions of the medial geniculate will be studied by placing deposits of two anterograde tracers in different frequency represenations of the inferior colliculus. Physiological studies of single units in the medial geniculate will then confirm the organization of convergent input, and identify the physiological responses of such neurons. These studies will provide information regarding integrative mechanisms by which sound location and other acoustic features are analyzed within the auditory system.