DEVELOPMENT OF NEW DENTAL COMPOSITE FORMULATIONS

本研究的长远目标是发展牙科复合材料。 它们对技术不那么敏感，更容易湿润的牙齿结构，以及 减少了固化收缩和吸水率。复合材料具有 与可用的替代材料相比有几个优势：直接 技术，美观的外观，以及对牙齿结构的粘合。连 因此，遗留的问题限制了它们在后部的更多使用 应用，其中四分之三的人仍在使用牙科汞齐 全部修复。 两个主要问题是无补偿造成的牙齿应力 固化收缩，以及将电流材料与 放置过程中的水分，这需要使用要求严格的 不受欢迎的临床程序。解决这些问题的紧迫性是 增加了牙科汞齐(唯一的替代方案)的可能性 直接材料)，可能会因为汞危害而被禁止。 本研究建议制备并评价该系列复合材料。 以新合成的基质单体为基础的材料。这项工作是 基于这样一种假设，当前材料的问题是 主要是由于需要控制的稀释剂单体的数量 基质粘度大，因此使用的基质单体较低 粘度将导致性能的改善。最近在这方面的试点工作 实验室已经证实了这一假设。修改 将制备传统的BIS-GMA单体以及两个系列的 中心-C(CH3)2-被以下基团取代的单体 磷或氟。在每个系列中将制备三个单体。 一种具有BIS-GMA的侧基特征，另一些具有 -OH被-H和-CH3取代。综合方案和条件为 调整以避免氢键和齐聚，从而最大限度地减少 粘度。当纯单体的粘度超过粘度时 目前未固化的基质材料的特点，它将被稀释 根据需要使用TEGDM来产生标准粘度。每种材料都将 被评价为单体、未填充的聚合物和 一种混杂复合材料。将测试单体的粘度、润湿性 性能、吸水率和固化收缩。聚合物和 将测试复合材料的吸水率、吸水能力和 唾液，以及一系列物理和机械特性。

The long range goal of this study is the development of dental composites which are less technique sensitive, wet tooth structure more readily, and have reduced curing shrinkage and water sorption. Composites have several advantages over available alternative materials: direct technique, esthetic appearance, and adhesion to tooth structure. Even so, remaining problems limit their increased use in posterior applications, where dental amalgams are still used in three-fourths of all restorations. Two major problems are stresses in the tooth created by uncompensated curing shrinkage, and the necessity of isolating current materials from moisture during placement, which requires the use of demanding and unpopular clinical procedures. The urgency of solving these problems is increased by the possibility that dental amalgam, (the only alternative direct material), may be banned because of mercury hazards. This study proposes to prepare and evaluate the series of composite materials based upon newly synthesized matrix monomers. The work is based upon the hypothesis that the problems with current materials are largely due to the quantity of diluent monomers required to control matrix viscosity, and therefore that the use of matrix monomers of lower viscosity would lead to improved properties. Recent pilot work in this laboratory has confirmed this hypothesis. Modifications of the traditional BIS-GMA monomer will be prepared, as well as two series of monomers in which the central -C(CH3)2- is replaced by groups containing phosphorous or fluorine. In each series three monomers will be prepared. One with pendant -OH group characteristic of BIS-GMA, and others with the -OH replaced by -H and -CH3. Synthesis schemes and conditions will be adjusted to avoid hydrogen bonding and oligomerization, thus minimizing viscosity. Where the viscosity of the pure monomer exceeds the viscosity characteristic of present uncured matrix materials, it will be diluted with TEGDM as needed to produce a standard viscosity. Each material will be evaluated as a monomer, as the unfilled polymer and as the matrix of a hybrid composite. The monomers will be tested for viscosity, wetting ability, water sorption and curing shrinkage. The polymers and composites will be tested for water sorption, we ability by water and saliva, and a series of physical and mechanical properties.