Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance

在我们的新陈代谢过程中产生的活性中间体有助于衰老。Glycoproteinase-1是一种关键的防御酶，可以抵抗这些有毒的中间体，从而使自身衰老。本项目旨在研究新的途径，如何表达和活性的glycoprotease-1的调控。这个跨学科的项目希望通过结合相关的细胞和动物模型，蛋白质化学，表观遗传学和结构生物学来产生新的理解。预计这项工作将增进对这一基本生物防御的了解。这将使我们能够确定潜在的手段，以提高glycoproteinase-1的能力，以未来的生物老化的好处。

Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epigenetics and structural biology. It is expected that this work will improve understanding of this fundamental biological defence. This will allow us to identify the potential means to enhance the capacity of glyoxalase-1 to the future benefit of biological ageing.