PROSTAGLANDIN REGULATION IN VASCULAR ENDOTHELIUM

血管内皮细胞在维持止血和 血管张力。由于其独特的地理位置，它很容易暴露在 循环介质，其中许多影响基础细胞 流程。肿瘤坏死因子是一种炎性介质 这会严重影响内皮细胞的功能。 这项名为《血管内皮细胞前列腺素调节》的提案， 将探索内皮细胞生理紊乱的一个重要方面 肿瘤坏死因子：前列腺素合成的调节。 这个项目将专门研究肿瘤 坏死因子促进内皮细胞的前列腺素代谢。 肿瘤坏死因子和前列腺素在许多人类 条件。

The vascular endothelium is important in maintaining hemostasis and vascular tone. Because of its unique location, it is readily exposed to circulating mediators, many of which influence fundamental cellular processes. Tumor necrosis factor is one of the inflammatory mediators that critically affects endothelial cell function. This proposal, entitled Prostaglandin Regulation in Vascular Endothelium, will explore an important aspect of endothelial cell physiology disrupted by tumor necrosis factor: the regulation of prostaglandin synthesis. This project will specifically examine the mechanism whereby tumor necrosis factor increases prostaglandin metabolism in endothelial cells. Tumor necrosis factor and prostaglandins play a role in a number of human conditions.