MAGNESIUM AND SICKLE CELL DISEASE

描述：镰状细胞性贫血是一种由多器官系统引起的疾病 由于HBS的反常物理性质。哈佛商学院有独特的趋势 在循环中聚合和扭曲红细胞，导致广泛的 血管功能不全。聚合(和镰刀状)倾向 含HbS的红细胞与HbS浓度呈指数关系 在牢房里。镰刀本身会导致细胞失去水分和KCL， 随着细胞脱水，进一步加剧了镰状细胞。RBC镁发挥作用 在控制细胞水分含量、体积和细胞膜方面发挥核心作用 正常红细胞和镰状红细胞的功能。钾-氯共转运系统 参与镰状红细胞的脱水，被显著抑制 提高细胞的镁含量。有报道称，镁的含量 SS细胞密度减少。中国人的膳食镁摄入量 目前还没有对SS患者进行研究。这项建议的具体目的 以下是：1)评估糖尿病患者的膳食镁摄入量 2)研究红细胞镁的调节作用及镁的影响。 正常和镰刀型的离子转运和其他膜功能 红细胞和遗传决定的高镁和低镁小鼠 3)评价补镁对SS的影响 病人。

DESCRIPTION: Sickle cell anemia is a multi organ system disease caused by the abnormal physical properties of HbS. HbS has the unique tendency to polymerize and distort RBC in the circulation, resulting in widespread vascular insufficiency. The polymerization (and sickling) tendency of HbS- containing RBCs is exponentially related to the concentration of HbS in the cell. Sickling itself causes the cell to lose water and KCL, further exacerbating sickling as cells become dehydrated. RBC Mg plays a central role in the control of cell water content, volume and membrane functions in normal and sickle RBCs. K-Cl cotransport, a system involved in dehydration of sickle RBCs, is markedly inhibited by increasing cell Mg. There are reports which claim that Mg content of dense fraction of SS cells may be decreased. Dietary intake of Mg in SS patients has not been studied. The specific aims of this proposal are the following: 1) Assess the dietary intake of Mg in patients with SS disease; 2) study the regulation of RBC Mg and the effects of Mg on ion transport and other membrane functions in normal and sickle erythrocytes and in genetically determined high Mg and low MG mouse erythrocytes; 3) assess the effect of dietary Mg supplementation in SS patients.