Modeling the cost of a process for the manufacture of succinic acid by fermentation of syngas

该项目将开发BioSyntha公司通过发酵木质纤维素生物质制成的合成气来合成平台化学品的新技术的过程经济学模型。该模型将支持BiSyntha从其研发中最大化和提取价值的商业计划。合成气体发酵在世界上尚处于起步阶段，目前还没有现成的合成气体发酵过程模型。该项目将通过使目标产品产量和生产率等工艺参数与代谢工程目标保持一致，帮助将这项技术开发成完全商业化的产品。对通过发酵方法将来自多种灵活来源的合成气转化为平台化学品的原则进行经济验证，并与替代路线进行比较，将使该公司能够吸引更多投资，并与行业合作伙伴发展合作关系。

This project will develop a model of the process economics of BioSyntha's novel technology for synthesis of platform chemicals by fermentation of syngas made from lignocellulosic biomass. The model will underpin Biosyntha's business plan to maximise and extract value from its R&D. Syngas fermentation is in its infancy in the world and there is no readily available model for syngas fermentation processes. This project will assist in the development of this technology into full commercial production by aligning process parameters such as target product yields and production rates, with metabolic engineering objectives. Economic validation of the principle of converting syngas derived from multiple and flexible sources to platform chemicals by a fermentative approach, and comparison with alternate routes, will allow the company to attract further investment and to develop collaborative relationships with industrial partners.