Promoters for Improved Protein & Biopharmaceutics Production in Mammalian Cells

增强蛋白质表达的方法对于新药开发和生物药物的有效生产至关重要。该联盟的目标是开发一种设计和构建合成启动子的新方法，这些启动子可以在工业规模上用于驱动商业应用的蛋白质表达。这将通过将Synprostaglandin的合成启动子设计能力与Genabler的改进DNA组装方法和爱丁堡大学Synthprostaglandin研究所的系统生物学专业知识相结合来实现。该项目将产生一种新的平台技术，可用于创建在生物技术领域具有多种应用的合成启动子。这一初步可行性研究将结合三个合作伙伴的不同专业知识，以构建能够提高哺乳动物细胞培养系统中蛋白质产量的合成启动子，以期提高蛋白质产量和质量。

Enhancing methods of protein expression is fundamentally important to new drug development and the efficient production of biopharmaceuticals. The consortium aims to develop a novel means of designing and constructing synthetic promoters that can be employed on an industrial scale to drive the expression of proteins for commercial applications. This will be achieved by combining the synthetic promoter design capabilities of Synpromics with improved DNA assemble methodology from Genabler and systems biology expertise from the SynthSYS institute of the University of Edinburgh. The project will yield a novel platform technology that can be used to create synthetic promoters with multiple applications across the biotech sector. This initial feasibility study will incorporate disparate expertise from the three partners to construct synthetic promoters that can enhance the production of proteins in mammalian cell culture systems, with a view to improve upon protein yield and quality.