Non-invasive identification and monitoring of Inflammatory Bowel Disease (IBD)

本项目评估一种新的、无创的克罗恩病和溃疡性结肠炎诊断和监测试验的可行性。该测试基于使用新型离子迁移技术检测生物样品中的VOC生物标记物。克罗恩病和溃疡性结肠炎尤其令人不快，每250人中就有1人受到影响。症状包括急迫带血的腹泻、疼痛和持续的疲劳，以及深度溃疡和肠壁疤痕。目前的诊断方法是高度侵入性的；基于血液检查和内窥镜检查（每个直肠的相机检查）。英国国家医疗服务体系每项手术的费用为500英镑，英国每年约有18万例手术。我们创新的一步是用一种简单、低成本（低于10英镑）的尿液或粪便测试来取代这种方法，该测试基于对这些生物样本中释放的VOC生物标志物的检测和分析。

This project evaluates the feasibility of a novel, non-invasive diagnosis and monitoring test for crohn’s disease and ulcerative colitis. The test is based on the detection of VOC bio-markers in biological samples using a novel form Ion Mobility technology. Crohn’s disease and ulcerative colitis are particularly unpleasant affecting 1 in 250 of the population. Symptoms range from urgent and bloody diarrhea, pain and continual tiredness to deep ulcers and scarring to the wall of the intestine. Current diagnostic methods are highly invasive; being based on blood tests and endoscopic examinations (camera examination per rectum). The cost to the NHS is set at £500 per procedure with around 180,000 procedures undertaken per annum in the UK. Our innovative step is to replace this with a simple, low-cost (sub £10) urine or stool test based on the detection and analysis of VOC biomarkers released from these biological samples.