NEUROMAGNETIC MAPPING OF MULTIPLE VISUAL AREAS IN HUMANS

该建议旨在识别和表征多种视觉 通过使用神经磁测量， 结合磁共振成像技术。尽管先前 非侵入性研究已经显示了人类原始视网膜病变的证据， 大脑，缺乏对这种视网膜病变的更全面的描述。那里 没有任何研究系统地研究了 视野表征或这些表征的特定功能 地区本实验采用瞬态诱发反应 技术，将分两个阶段进行：1）视网膜定位映射， 2)视觉区域的功能表征。 将通过标测神经磁场进行视网膜定位标测 小圆形正弦（目标）刺激诱发的分布， 不同的偏心率平行于垂直方向， 水平子午线和视野中的45度对角线上。 视觉区的功能表征将集中在操纵 颜色，因为该参数已成功区分 非人类灵长类动物的视觉区域。色彩对比度和亮度 正弦光栅将被操纵， 激活颜色/形式系统。 该项目的长期目标是划定具体的 人类大脑中的信息处理路径。功能 不同视觉区域的表征将最终有助于 更好地理解高级认知功能。

This proposal is aimed at identifying and characterizing multiple visual areas in the human brain through the use of neuromagnetic measurements, in conjunction with magnetic resonance imaging techniques. Although previous noninvasive studies have shown evidence of crude retinotopy in the human brain, a more thorough description of this retinotopy is lacking. There have been no studies which have systematically examined the arrangement of the visual field representations nor the specific functions of these areas. The experiments proposed here, using transient evoked response techniques, will be carried out in two phases: 1) retinotopic mapping and 2) functional characterization of visual areas. Retinotopic mapping will be performed by mapping neuromagnetic field distributions evoked by small circular sinusoid (Target) stimuli of differing eccentricity presented in parallel with the vertical and horizontal meridians and on 45 degree diagonals in the visual field. Functional characterization of visual areas will focus on manipulations of color since this parameter has been successful in differentiating between visual areas in nonhuman primates. The chromatic contrast and luminance of sinusoidal gratings will be manipulated in order to preferentially activate the color/form system. The long-term goal of the project is the delineation of specific information processing pathways in the human brain. The functional characterization of the different visual areas will ultimately aid in a better understanding of higher cognitive functions.