IMAGING THE DEVELOPMENT OF MEMORY STRAEGIES IN AGING

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to use magnetoencephalography or MEG to examine episodic memory function, along with measures of white matter integrity (i.e., MR morphometry, classification of white matter hyperintensities and fractional anisotrophy of FA) and cognitive integrity (i.e., neuropsychological tests), to demonstrate that healthy 'successful' aging is quite different from 'normal' aging since the latter may include pathological processes such as hypertension and diabetes which can increase the risk for dementia. The importance of this distinction is that some pathological processes contributing to cognitive decline can be controlled or prevented.