IMAGING THE DEVELOPMENT OF MEMORY STRAEGIES IN AGING

想象衰老过程中记忆策略的发展

• 批准号: 7716612
• 负责人: CHERYL J AINE
• 金额: $ 0.48万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716612
• 关键词: Aging; Classification; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Dementia; Development; Diabetes Mellitus; Episodic memory; Funding; Grant; Hypertension; Image; Impaired cognition; Institution; Magnetoencephalography; Measures; Memory; Neuropsychological Tests; Pathologic Processes; Research; Research Personnel; Resources; Risk; Source; United States National Institutes of Health; morphometry; normal aging; prevent; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to use magnetoencephalography or MEG to examine episodic memory function, along with measures of white matter integrity (i.e., MR morphometry, classification of white matter hyperintensities and fractional anisotrophy of FA) and cognitive integrity (i.e., neuropsychological tests), to demonstrate that healthy 'successful' aging is quite different from 'normal' aging since the latter may include pathological processes such as hypertension and diabetes which can increase the risk for dementia. The importance of this distinction is that some pathological processes contributing to cognitive decline can be controlled or prevented.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们建议使用脑磁图或脑磁图来检查情景记忆功能，以及白质完整性的测量(即MR形态测量、白质高信号分类和FA的部分各向异性)和认知完整性(即神经心理测试)，以证明健康的“成功”衰老与“正常”衰老有很大的不同，因为后者可能包括高血压和糖尿病等可能增加痴呆症风险的病理过程。这一区别的重要性在于，导致认知能力下降的某些病理过程是可以控制或预防的。