3D-DIP-ChIP: an 'omics'-based method for measuring genotoxin induced DNA damage

各行各业正在产生越来越多的创新化合物和产品，这些化合物和产品有可能为社会带来巨大的利益。这些新化合物中的许多将被纳入产品中，这些产品将带来持续的经济增长并提高全球生活水平。然而，这些新材料的安全引进和发布需要在使用之前进行安全评估。目前，许多方法都是在上个世纪中期发展起来的，并且严重依赖于动物的使用。越来越明显的是，这些方法存在局限性，包括速度、使用规模、各种结果的准确性和可预测性以及与人类环境的相关性。现在，全球正在共同努力开发新的非动物方法，以更快、更准确地预测正在生产的新化合物的安全性。本项目中描述的工作将评估在英国开发的一种利用基因组技术用于评估新材料的新方法的潜力。

Industries across a broad spectrum of sectors are now generating increasing numbers of innovative and novel compounds and products, which have the potential to bring enormous benefits to society. Many of these novel compounds will become incorporated into products that will bring continued economic growth and improve global living standards. However, the safe introduction and release of these new materials into the world requires safety assessment prior to their use. At the moment, many of the methods employed to do this were developed in the middle of the last century, and rely heavily on the use of animals. It has become increasingly clear that these methods have limitations, including their speed, scale of use, accuracy and predictivity of various outcomes and relevance to the human context. There is now a concerted global effort to develop novel non-animal methods that will more quickly and accurately predict the safety of novel compounds being produced. The work described in this project will evaluate the potential of a novel method developed in the UK using genomic technology to be used in the assessment of novel materials.