Real time visualisation & modelling of biofilm inhibition by lactam

微生物控制活性物质推动快速消费品配方、包装和加工中的卫生性能或防腐性。今天的石化选择正在接受安全，监管和非政府组织的压力，并已被证明是无效的惰性或生物表面上建立的生物膜。目前的清洁产品含有抗菌活性物质，通过杀死有害微生物来改善表面卫生和新鲜度。工业界对商业化抗生物膜技术的兴趣越来越大，这推动了健康和卫生的界限。呋喃酮衍生的内酰胺类似物干扰群体感应。迄今为止，它是不完全理解的过程中的哪个阶段（S）的影响。该项目旨在可视化实时表型变化的非嗜热菌诱导的可溶性内酰胺类似物和串联模型的非嗜热细胞表面协会的最早阶段，对成熟的生物膜结构和功能的持久影响。湍流动力学将揭示细胞吸引力和主动扩散性，并帮助我们确定生物膜生长抑制的限制因素，并设计新的或互补的抗生物膜技术。

Microbial control actives drive hygiene performance or preservation in FMCG formulations, packaging, andprocessing. Today's petrochemical options are receiving safety, regulatory and NGO pressure and have beenshown to be ineffective on established biofilms on inert or biological surfaces. Current cleaning productscontain anti-microbial actives that improve surface hygiene and freshness by killing planktonic microbes. Thereis increased industrial interest in commercialising anti-biofilm technologies that push the boundaries in healthand hygiene. Furanone derived lactam analogues jam quorum sensing. To-date it is not fully understood whichstage(s) of the process they impact on. This project aims to visualise in real-time phenotypic changes to non-planktonic bacteria induced by a soluble lactam analogue and in tandem model the very earliest stages of non-planktonic cell-surface association to lasting impact on mature biofilm structure and functionality. Monitoringflow dynamics will shed light on cellular attraction and active diffusivity and help us identify the limitingfactor(s) in biofilm growth inhibition and design novel or complementary anti-biofilm technologies.