Methods of Microbial Control in the Clostridial ABE Fermentation Process (MiCON)

Green Biologics是一家工业生物技术公司，目前正在重新商业化利用可再生和可持续原料生产正丁醇和丙酮的梭菌发酵工艺。这一商业化过程中存在许多固有的挑战，不仅仅是工程和工艺设计的复杂性，还包括确保所使用的梭菌菌株表现出强大的表型，如对噬菌体感染的抗性，以及与植物环境中原生微生物竞争的能力。该项目旨在使用一种创新且对环境负责的替代方法来替代使用抗生素的“简单修复”解决方案，而不是利用细菌素：细菌素是由许多细菌菌株产生的小肽，用于破坏环境空间中的竞争微生物。

Green Biologics is an industrial biotech company, currently re-commercialising the clostridial ABEfermentation process for the production of n-butanol and acetone from renewable and sustainablefeedstocks. There are many challenges inherent in this commercialisation process, not just with thecomplexities of engineering and process design but also with ensuring the clostridial strains used exhibitrobust phenotypes such as resistance to phage infections and ability to out compete microbesindigenous to the plant environment. This project aims to use an innovative and environmentallyreponsible alternative approach to the ‘easy fix’ solution of using antibiotics by instead taking advantageof bacteriocins: small peptides produced by a number of bacterial strains to destroy competingmicrobes in an environmental space.