BIOMECHANICS OF THE MITRAL VALVE

拟议的研究的目的是量化机械 心脏二尖瓣组织的特性及其与二尖瓣病变的关系 微观结构。由于在体内的应力不能直接在 将实验数据和工程分析相结合的阀门 需要估计不同应力分量的分布。一 应力预测的基本组成部分是本构关系， 形式化地描述组织应力和应变之间的关系。 本申请建议制定一个合适的本构关系 对于二尖瓣组织，合并了区域变异和 与下面的组织微结构的关系。努力实现 了解阀门内的法向应力分布及其 微观结构基础可能有助于洞察应激在 疾病状态下的结构重塑

The purpose of the proposed research is to quantify the mechanical properties of cardiac mitral valve tissue and their relationship to the microstructure. Since in vivo stress cannot be measured directly in the valve a combination of experimental data and engineering analysis is needed to estimate the distribution of different stress components. One essential component of a stress prediction is a constitutive relation, formally describing the relationship between tissue stress and strain. This application proposes to formulate a suitable constitutive relation for mitral valve tissue, incorporating regional variations and a relationship to the underlying tissue microstructure. Efforts to understand the normal stress distribution in the valve and its microstructural basis may yield insight into the role of stress in structural remodeling in disease states