REGIONAL MYOCARDIAL PERFUSION & MECH USING 3D MYOCARDIAL CONTRAST ECHOCARDIO

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是： A.在心脏有限元模型中实现灌流心肌的均质化描述，并使用三维超声成像对该模型进行验证。 采用非线性横观各向同性材料描述，建立二尖瓣的有限元模型，并用三维变形数据进行验证 C.研究左心辅助装置与心脏和心血管系统的流体力学相互作用。 我们目前正在使用连续性对心脏和瓣膜进行固体力学建模，特别是将我们自己的材料描述整合到软件中的能力。一个新的项目(C)专注于流体力学，因此，将连续性解决方案与我们的CFD软件耦合或接口的能力将使我们能够研究这一领域非常感兴趣的固体-流体相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aims of this research are: a. To implement a homogenization description of perfused myocardium into a finite element model of the heart, and validate this model using 3-D ultrasound imaging. b. To develop a finite element model of the mitral valve using a nonlinear transversely isotropic material description, and validate it using 3-D deformation data c. To study the fluid mechanics interaction of the native heart and cardiovascular system with left ventricular assist devices. We are presently using Continuity for solid mechanics modeling of the heart and valve, particularly the ability to integrate our own material descriptions into the software. A new project (c) is focused on fluid mechanics, so the ability to couple or interface solutions from Continuity with our CFD software would enable the study of solid-fluid interactions which are of great interest in this area.