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SYNTHESIS OF NOVEL MARINE HETEROCYCLES

SYNTHESIS OF NOVEL MARINE HETEROCYCLES
新型海洋杂环化合物的合成
批准号：
3303968
负责人：
MICHAEL P CAVA
金额：
$16.23万
依托单位：
UNIVERSITY OF ALABAMA IN TUSCALOOSA
依托单位国家：
美国
项目类别：
财政年份：
1991
资助国家：
美国
项目状态：
已结题
起止时间：
1991-05-01 至 1995-04-30
来源：
https://reporter.nih.gov/project-details/3303968
关键词：
Porifera Tunicata X ray crystallography alkaloids alternatives to animals in research antineoplastics antiviral agents chemical structure chemical structure function chemical synthesis cytotoxicity drug adverse effect heterocyclic compounds indoles marine biology tissue /cell culture

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中文摘要
翻译
近年来，一些具有不寻常生物活性的化合物， 杂环结构已经从多种海洋生物中分离出来 生物，特别是海绵和被囊动物。 这项提案的目的是 其中四种化合物的全合成，所有这些化合物都是新的 海洋吲哚生物碱 它们包括细胞毒性海绵生物碱 discorhabdin C、prianosin A、manzamine C和dragmacidin。 所有上述 表示尚未合成的结构类型。
英文摘要
In recent years, a number of biologically active compounds having unusual heterocyclic structures have been isolated from a variety of marine organisms, especially sponges and tunicates. The goal of this proposal is the total synthesis of four of these compounds, all of which are novel marine indole alkaloids. They include the cytotoxic sponge alkaloids discorhabdin C, prianosin A, manzamine C and dragmacidin. All of the above represent structural types which have not yet been synthesized.
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SYNTHESIS OF NOVEL MARINE HETEROCYCLES
SYNTHESIS OF NOVEL MARINE HETEROCYCLES
SYNTHESIS OF NOVEL MARINE HETEROCYCLES
SYNTHESIS OF TROPLOISOQUINOLINE ALKALOIDS
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