CAPPING INTERACTIONS AND HELIX STABILIZATION

这项研究有助于解决折叠问题，即 从氨基酸预测蛋白质的空间结构 ITS多肽链序列。考虑到地震的严重程度 折叠问题，本项目考虑的是一种常见的预测 空间蛋白质的亚结构，即O‘-螺旋。拟议的研究将 研究侧链/多肽骨架氢的贡献 螺旋末端区域中的键合相互作用(封端) 两者都终止和稳定螺旋结构。的影响 系统氨基酸残基替代对螺旋体含量的影响 模型多肽将使用圆二色谱和核磁共振进行评估 测量。这些影响--以AA-G值表示--将是 引入现代螺旋线预报算法 结构。

This research contributes to the solution of the folding problem, the prediction of the spatial structure of a protein from the amino acid sequence of its polypeptide chain. In deference to the magnitude of the folding problem, this project considers the prediction of a common spatial protein substructure, the o'-helix. The proposed research will investigate the contribution of side-chain/polypeptide backbone hydrogen bonding interactions (capping) in the terminal regions of a helix which both terminate and stabilize the helical structure. The effect of systematic amino acid residue replacements on the helical content of model peptides will be evaluated using both circular dichroism and NMR measurements. These effects- expressed as AA G values, will be introduced into contemporary algorithms for prediction of helical structure.