Structure guided mapping of protein interactions and their perturbation

蛋白质相互作用是大多数生物过程的核心，人们一直在努力解开这些复杂的网络。该项目旨在开发新的方法来更好地理解这些相互作用及其扰动的后果。主要的预期贡献将是：(i)利用种群保护确定可能的蛋白质相互作用位点的方法；（ii）评估任何类型突变对相互作用影响的计算方法；（iii）了解特定相互作用的破坏如何影响细胞内复杂的生物网络。

Protein interactions are central to most biological processes, and significant effort has been devoted to trying to unravel these complicated networks. This project aims to develop new approaches to better understand these interactions, and the consequences of their perturbation. The main expected contributions will be: (i) methods to identify likely protein interaction sites using population conservation; (ii) computational approaches to assess the effects of any type of mutation on the interaction; and (iii) an understanding of how disruption of a specific interaction can affect the complicated biological network within a cell.