EVENT RECORDINGS OF HIGH RISK INFANTS ON APNEA MONITORS

该提案是作为多中心协作研究的一部分设计的 在呼吸暂停监护仪上记录高危婴儿的事件。病人们， 描述了人员和设施。这些都证明了 卡皮奥拉尼妇幼医学中心选址的适宜性 为了这项研究。该建议将确定(A)频率， 心肺改变(CRA)的持续时间和类型 事件“监测婴儿呼吸暂停的警报；(B)遵从性；和(C) 记录报警事件的生理和临床意义。这个 家庭将使用Aequitron 9600和兼容设备 监控。 拟议的研究将评估探索性假设，包括 与此相关的适当统计模型和显著性检验 (1)围产期不良事件对CRA的影响(2)CRA与 中枢神经系统和自主神经系统的成熟水平，(3) 加强遵从性对家庭事件监测的影响，(4)家庭 监测不同种族/族裔群体的遵守情况；以及(5) 婴儿呼吸暂停对神经行为发育的影响学习 患者将被诊断为高加索人、夏威夷人和菲律宾婴儿 早产儿呼吸暂停，用柠檬酸咖啡因治疗 Alte和小岛屿发展中国家受害者的兄弟姐妹。进入后，婴儿将被 分配到家庭呼吸暂停监测计划，并在呼吸暂停后出院 解决了。除了“真正的警报”记录外， 假设将基于多导睡眠图、迷走神经紧张度测量和 声学哭声分析。 该研究计划涉及一个试点年，基于大约60个 婴儿和预计的随访年数以及与以下方面有关的细节 扩张。修改受协作和合作的约束 协议。

This proposal is designed as part of a multi-center collaborative study on event recordings of high risk infants on apnea monitors. Patients, personnel and facilities are described. These demonstrate the suitability of Kapiolani Medical Center for Women and Children as a site for this study. This proposal will determine the (a) frequency, duration, and type of cardiorespiratory alterations (CRA) based on "true event" monitor alarms in infantile apnea; (b) compliance, and (c) the physiologic and clinical significance of recorded alarm events. The Aequitron 9600 and compatible equipment will be used for home monitoring. The proposed study will evaluate exploratory hypotheses, with appropriate statistical models and tests of significance related to the (1) effect of adverse perinatal events on CRA (2) relation of CRA to the maturational level of the central and autonomic nervous system, (3) effect of enhanced compliance on home event monitoring, (4) home monitoring compliance in different racial/ethnic groups, and (5) the impact of infantile apnea on neurobehavioral development. Study patients will be Caucasian, Hawaiian, and Filipino infants diagnosed with apnea of prematurity and treated with caffeine citrate, infants with ALTE and siblings of SIDS victims. After entry, infants will be assigned to a Home Apnea Monitor Plan, and discharged after apnea is resolved. In addition to "true alarm" recordings, data for the hypotheses will be based on polysomnograms, vagal tone measures, and acoustic cry analyses. The research plan involves a pilot year based on approximately 60 infants and projected follow-up years as well as details related to expansion. Modifications are subject to collaborative and cooperative agreements.