PREVENTION OF HIGH BLOOD PRESSURE IN CHILDREN

血压变化和血压升高的个体差异可能 部分原因是BP和BP的监管机制不同 反应性。此项目有两个相关组件：1)继续 纵向评估血压，体重，身高，体脂分布， 等，在每半年进行一次检查的817名受试者中 自1978年以来；以及2)比较一组“高风险”受试者(顶部 连续三次收缩压的五分之一)到随机的 选取对照组，探讨其与血浆的关系 胰岛素和(BP)及BP反应性作为肥胖、脂肪的函数 分布、儿茶酚胺浓度和钠通量。建议数 这项研究将重新检查817名年龄在18-21岁之间的健康男性和女性 自1978年以来参与了明尼阿波利斯儿童BP研究。我们会 评估儿童至青年血压变化的纵向预测因素 成人期。体细胞生长、体脂分布、亲本的影响 血压与肥胖，以及几种健康习惯和行为对血压的影响会发生变化 根据过去12年来反复采取的措施估计。这个 这项研究的第二部分将评估 胰岛素与血压和血压反应性在一组高血压高危人群中的研究 另设原发性高血压组和对照组。我们将对葡萄糖进行定量 和胰岛素(空腹和葡萄糖负荷后)，血清浓度 肾上腺素和去甲肾上腺素以及钠在红血球中的转运 以更好地研究它们与BP的复杂相互关系。 肥胖、脂肪分布、体力活动和其他方面的差异 协变量将在分析中考虑在内。这项研究应该 提供有价值的洞察机制，通过这些机制 生物行为因素相互作用，影响血压调节。

Individual differences in blood pressure (BP) change and BP elevation may be due in part to differences in the mechanisms regulating BP and BP reactivity. This project has two related components; 1) to continue longitudinal assessments of BP, body weight, height body fat distribution, etc, in a cohort of 817 subjects who have been examined semi-annually since 1978; and 2) to compare a "high risk" group of subjects (top quintile of systolic BP on three consecutive occasions) to a randomly selected comparison group to explore the relationships between plasma insulin and (BP) and BP reactivity as a function of obesity, fat distribution, catecholamine concentrations, and sodium flux. The proposed study will reexamine 817 healthy men and women aged 18-21 years who have participated in the Minneapolis Children's BP Study since 1978. We will assess the longitudinal predictors of BP change from childhood to young adulthood. The effects of somatic growth, body fat distribution, parental BP and obesity, and several health habits and behaviors on BP change will be estimated from repeated measures taken over the last 12 years. The second component of this study will evaluate the association between insulin and BP and BP reactivity in a group of subjects at risk for essential hypertension and a comparison group. We will quantitate glucose and insulin (fasting and after a glucose load), serum concentrations of epinephrine and norepinephrine, and sodium transport across the red blood cell membrane to better study their complex interrelationships with BP. Differences in obesity, fat distribution, physical activity and other covariates will be taken into account in the analyses. This study should provide valuable insight into mechanisms through which physiologic and biobehavioral factors interact to effect blood pressure regulation.