BIOBEHAVIOR, ETHNICITY, HORMONES & BLOOD PRESSURE

生物行为、种族、激素

• 批准号: 3363414
• 负责人: RICHARD P DONAHUE
• 金额: $ 52.91万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 1995-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3363414
• 关键词: African American; Hispanic Americans; adult human (21+); aggression; angers; biological transport; blood lipoprotein; calcium flux; catecholamines; caucasian American; dietary sodium; ethnic group; hormone regulation /control mechanism; human middle age (35-64); human subject; hypertension; insulin; obesity; racial /ethnic difference; rest

Ethnic differences in hypertension and hypertension-related diseases may be due to differences in the mechanisms regulating blood pressure (BP) and BP reactivity. This project will examine the relationship between plasma insulin on the one hand and blood pressure (BP) and BP reactivity on the other as a function of obesity, fat distribution, lipoprotein profile, catecholamine concentrations, sodium flux, and ionized calcium concentration. The proposed study will examine 480 healthy men and women aged 25-44 years from three ethnic groups: 1) white nonHispanics; 2) black non-Hispanics; and 3) white Cuban Americans. We will assess BP and BP reactivity under three experimental conditions: 1) at rest; 2) in response to three standardized behavioral tasks in the laboratory; and 3) while ambulatory in naturalistic settings. Several psychosocial dimensions of behavior will be measured including anger and hostility. We will quantitate several hormones including insulin (fasting and after a glucose load), epinephrine and norepinephrine, cortisol, plasma renin activity, and aldosterone to better study their interrelationships with BP. We will also investigate the influence of sodium transport on blood pressure and how sodium transport is effected by hormones. In addition, the role of hormones on ethnic differences in the lipoprotein profile will be studied. Ethnic differences in obesity, fat distribution, physical activity and other covariates will be taken into account in the analyses. This study should provide valuable insight into mechanisms through which biobehavioral factors interact to affect blood pressure regulation.

高血压及高血压相关疾病的种族差异可能 是由于调节血压（BP）的机制和 BP反应性。该项目将研究血浆之间的关系 一方面是胰岛素，另一方面是血压 (BP) 和血压反应性 其他与肥胖、脂肪分布、脂蛋白分布有关的函数， 儿茶酚胺浓度、钠通量和离子钙 专注。拟议的研究将对 480 名健康男性和女性进行检查 年龄 25-44 岁，来自三个种族群体：1) 非西班牙裔白人； 2) 黑色 非西班牙裔； 3）古巴裔美国人。我们将评估BP和BP 三种实验条件下的反应性：1) 静止； 2）响应 实验室中的三项标准化行为任务； 3）同时 在自然主义环境中行走。几个心理社会维度 行为将被测量，包括愤怒和敌意。我们将量化 多种激素，包括胰岛素（空腹和葡萄糖负荷后）， 肾上腺素和去甲肾上腺素、皮质醇、血浆肾素活性，以及 醛固酮以更好地研究它们与血压的相互关系。我们还将 研究钠转运对血压的影响以及如何 钠转运受激素影响。另外，荷尔蒙的作用 将研究脂蛋白谱的种族差异。种族的 肥胖、脂肪分布、体力活动等方面的差异 分析中将考虑协变量。这项研究应该 提供对生物行为机制的宝贵见解 因素相互作用影响血压调节。