Induced Pluripotent Stem Cell technology for Drug Discovery and Personalized Medicine

自2006年问世以来，诱导多能干细胞（iPSC）已被证明在疾病建模、药物发现和再生医学方面具有巨大潜力。通过基因改造，已经分化为特定组织的成年细胞被恢复或“重新编程”为胚胎样状态，创造出具有自我更新特性的细胞，并有可能被定向为体内任何细胞类型。人类iPSC可以从血液中获得，不仅可以规避人类胚胎干细胞（ESC）带来的伦理问题，而且可以轻松生产[患者特异性][0] [多能干细胞][1]用于个性化治疗。研究人员现在可以从患者血液中产生iPSC衍生的心脏、神经和视网膜细胞等，为发现和开发个性化医疗开辟了一条全新的途径。目前用于衍生和编程iPSC的过程缓慢、复杂且昂贵。ReproGO技术允许通过自动化系统快速生成人类iPSC，只需少量患者血液。通过允许具有成本效益，简单和可重复的患者iPSC生产，ReproGO将加速多种疾病新疗法的发现和开发。[0]：https://www.sciencedirect.com/topics/engineering/patient-specific“Learn more about Patient Specific from ScienceDirect's AI-generated Topic Pages”[1]：https://www.sciencedirect.com/topics/engineering/pluripotent-stem-cells“Learn more about Pluripotent Stem Cells from ScienceDirect's AI-generated Topic Pages”

Since their advent in 2006, induced pluripotent stem cells (iPSCs) have demonstrated a huge potential for disease modelling, drug discovery and regenerative medicine. Through genetic modification, adult cells already differentiated to specific tissues are reverted back, or 'reprogrammed' to an embryonic-like state, creating cells with self-renewal properties and the potential to be directed towards any cell type in the body. Human iPSCs can be derived from blood, and not only circumvent ethical issues presented by human embryonic stem cells (ESCs), but also enable the easy production of [patient-specific][0] [pluripotent stem cells][1] for individualised therapy. From patient blood, researchers can now generate iPSC-derived cardiac, neural and retinal cells among others, opening up a whole new avenue in the discovery and development of personalised medicine.Current process used to derive and programme iPSCs are slow, complex and expensive. The ReproGO technology allows human iPSCs to be generated rapidly by an automated system needing only a small volume of patient blood. By allowing a cost-effective, simple and reproducible production of patient iPSCs, ReproGO will accelerate the discovery and development of new therapies for multiple diseases.[0]: https://www.sciencedirect.com/topics/engineering/patient-specific "Learn more about Patient Specific from ScienceDirect's AI-generated Topic Pages"[1]: https://www.sciencedirect.com/topics/engineering/pluripotent-stem-cells "Learn more about Pluripotent Stem Cells from ScienceDirect's AI-generated Topic Pages"