HEART PROGRAM--STUDY OF STROKE AND DEMENTIA

这项调查的长期目标是开发更多 防治中风和痴呆相关疾病的有效方法 脑血管疾病。这项研究将基于以下数据 死亡男子的危险因素和尸检脑切片 火奴鲁鲁心脏计划。在这个队列中，血管内侧和内膜病变 脑实质动脉与脑密切相关 脑梗塞和死于中风的常见男性是非中风患者的3倍 心血管疾病。研究的具体目的是：1)划定 脑实质动脉的形态特征 病变、其区域解剖分布及其与 大鼠邻近脑实质改变与动脉粥样硬化程度 主要的颅内动脉；2)关系的特征 男性动脉病变与年龄增长之间的关系；3)特征 60-65岁以上男性动脉病变的关系 中风、脑梗塞或出血、痴呆症；4)识别 与动脉病变相关的其他危险因素。这个 动脉病变和邻近的脑实质将通过 常规组织学染色和免疫组织化学标记物 动脉壁的特定细胞和细胞外成分。这个 将确定每种类型的动脉病变的患病率和程度 在3个解剖部位。被认为与以下因素有关的基线风险因素 中风和脑梗塞将被检查是否与 动脉损伤。关联性的统计测试将基于 单变量和多变量线性和Logistic回归模型 在年龄需要时加以控制。这项研究将澄清 动脉病变与衰老的关系，确定动脉病变对衰老的影响 动脉改变与中风、脑梗塞和 并提供对血管性痴呆的更好的了解。 动脉病变的形态描述将有助于使用 研究病变潜在分子机制的实验模型 以及控制这些疾病的药理学方法的发展 机械装置。动脉病变危险因素的进一步检查 将表明有机会预防或改变它们的演变。

The long-term goal of this investigation is the development of more effective methods for preventing and treating stroke and dementia related to cerebrovascular disease. The study will be based on data including risk factors and autopsy brain sections from deceased men from the Honolulu Heart Program. In this cohort medial and intimal lesions of brain parenchymal arteries are significantly associated with brain infarction and 3 times more common men dying of stroke than of non- cardiovascular causes. The specific aims of the study are: 1) Delineation of the morphologic characteristics of the brain parenchymal artery lesions, their regional anatomic distribution, and their relationship to changes in adjacent brain parenchyma and the degree of atherosclerosis in the major intracranial arteries; 2) Characterization of the relationship in men between the arterial lesions and advancing age; 3) Characterization in men over 60-65 years of age of the relationship of the arterial lesions to stroke, brain infarction or hemorrhage, and dementia; 4) Identification of additional risk factors associated with the arterial lesions. The arterial lesions and adjacent brain parenchyma will be examined with conventional histologic stains and immunohistochemical markers for specific cellular and extracellular components of the arterial wall. The prevalence and extent of each type of arterial lesion will be determined at 3 anatomic sites. Baseline risk factors thought to be related to stroke and brain infarction will be examined for association with the arterial lesions. Statistical tests of association will be based on univariate and multivariate linear and logistic regression models controlled when necessary for age. The study will clarify the relationship of the arterial lesions to aging, define the influence of the arterial changes on the development of stroke, brain infarction, and dementia, and provide a better understanding of vascular dementia. Morphologic delineation of the arterial lesions will assist the use of experimental models to study molecular mechanisms underlying the lesions and the development of pharmacologic methods for controlling these mechanisms. Further examination of risk factors for the arterial lesions will indicate opportunities for prevention or modifying their evolution.