Sustainability and Supply Chain Benefits of Antibiotic Replacement Technology for Canadian and UK Livestock Sectors

饲料使用占家禽养殖温室气体排放量的78%。为了满足英国、加拿大对提高家禽生产可持续性的日益增长的需求，（和全球），该财团（Arden Biotechnology，UK & TrustBIX CA）希望解决家禽中的经济衰弱和饲料利用率低的疾病，即坏死性肠炎（NE）和亚临床坏死性肠炎（SNE），预防性抗生素生长促进剂（AGP）目前用于控制坏死性肠炎（NE），由病原体产气荚膜梭菌引起的一种肠道疾病。NE对肠道健康有重大影响，特别是在肉鸡行业，全球每年花费约60亿美元。预防性使用AGPs会对有益的肠道细菌产生负面影响，由于消费者的压力和对抗菌素耐药性的担忧，许多国家正在禁止或撤回AGPs。然而，在缺乏有效控制CP的情况下，这将增加FCR并威胁家禽生产的可持续性，导致需要更多的饲料和更长的生长期才能达到最佳体重。Arden Biotechnology，UK（Arden）开发了一种新型噬菌体鸡尾酒，一种天然饲料补充剂（NFS），以对抗CP，增强肠道健康并降低NE和SNE的风险。通过这个为期24个月的工业研究项目，雅顿正在寻求与TrustBIX Inc.合作，将这项技术的开发扩展到加拿大家禽和其他畜牧业。加拿大。随着行业逐渐放弃抗生素，家禽生产性能下降，治疗性抗生素使用增加。保持肠道健康的天然产品将在没有AGP的情况下提高家禽部门的可持续性，通过减少FCR，土地使用变化，粪便中挥发性固体的排泄和农场能源使用来显著减少温室气体排放。该项目将确认和预测这些可持续性声明，制定适当的指标，并开发一个平台，通过供应链跟踪使用雅顿Sustavian技术生产的食品，以货币化可持续性属性。该项目将通过使用噬菌体专门对抗CP来控制NE，从而为加拿大和英国家禽行业增加价值。它将进一步增强全国领先的可持续牲畜可追溯性平台，使其适用于家禽行业，并通过引入新的AI/ML功能来增强其分析能力，以支持数据质量和分析的增强。

Feed usage accounts for ~78% of poultry farming greenhouse-gas-emissions. In response to a growing demand to enhance sustainability in poultry production in the UK, Canada (and worldwide), the consortium (Arden Biotechnology, UK & TrustBIX CA) wishes to address the financially debilitating and poor feed utilising disease in poultry, necrotic enteritis (NE) and subclinical necrotic enteritis (SNE), by utilising bacteriophage technology.Prophylactic antibiotic growth promoters (AGPs) are currently used to control necrotic enteritis (NE), an enteric gut disease caused by the pathogen _Clostridium perfringens_ (CP). NE has a major impact on gut health, particularly in the broiler industry, costing it ~US$6billions per year globally. The prophylactic use of AGPs can negatively impact beneficial gut bacteria and is being banned or withdrawn in many countries due to consumer pressure and concerns on antimicrobial resistance. This will however increase FCR and threaten the sustainability of poultry production in the absence of an effective control for CP, causing more feed to be required and a longer growing period for birds to reach optimum weight.Arden Biotechnology, UK (Arden) have developed a novel bacteriophage cocktail, a natural feed supplement (NFS) to combat CP, enhance gut health and reduce the risk of NE and SNE. Through this collaborative 24 months industrial research project, Arden are seeking to extend the development of this technology to apply to the Canadian poultry and other livestock sectors in partnership with TrustBIX Inc. Canada.As the industry moves away from AGPs, poultry performance decreases and therapeutic antibiotic use increases. A natural product that maintains gut health will improve sustainability of the poultry sector in the absence of AGPs by effecting a significant reduction in greenhouse gas emissions by reducing FCR, land use change, excretion of volatile solids in manure and on farm energy use. This project is to confirm and predict these sustainability claims, develop appropriate metrics, and develop a platform to track food produced using Arden's Sustavian technology through the supply chain, to monetise the sustainability attributes.This project will add value to the Canadian and UK poultry sectors by delivering a control for NE using bacteriophage specifically to combat CP. It will further enable the enhancements to a nationally leading sustainable livestock traceability platform, adapting it for use in the poultry sector and enhancing its analytical capacity with the introduction of new AI/ML capabilities to support the enhancements of data quality and analysis.