DEVELOPING PROBES OF CORTICO-STRIATAL CIRCUITRY

这是为临床医生颁发NIMH科学家发展奖的请求 (K-20)，题为“开发皮质纹状体回路的探头”。这个 应聘者对神经精神障碍的神经科学感兴趣 累及基底节，尤其是强迫症 强迫症(OCD)和多发性抽动症(TS)。皮质-纹状体环路 与强迫症和TS的病理生理学有关。虽然融合了 数据表明，分离的皮质-纹状体环路排列在 平行的，分离的方式，以及不同的皮质纹状体 回路调节这两种疾病的症状，能力 从经验上检验这样的假设是有限的。候选人 建议设计和实施特定的激活范例以探索 分别使用正电子的离散平行皮质纹状体回路 发射断层扫描(PET)用于研究成人受试者。除了……之外 确定TS和强迫症中介神经解剖学的激活研究 将使用受体表征技术来探索可能的 纹状体内的神经化学异常。这样一个多方面的 研究皮质-纹状体环路的方法有望产生 有关强迫症、TS的重要信息以及强迫症的生理功能 皮质-纹状体系统。

This is a request for an NIMH Scientist Development Award for Clinicians (K-20) entitled "Developing Probes of Cortico-Striatal Circuitry." The candidate's interest is in the neuroscience of neuropsychiatric disorders involving the basal ganglia, particularly obsessive-compulsive disorder (OCD) and Tourette's disorder (TS). Cortico-striatal circuits have been implicated in the pathophysiology of OCD and TS. Although converging data suggest that separate cortico-striatal circuits are arranged in a parallel, segregated fashion, and that different cortico-striatal circuits mediate the symptoms of the two disorders, the capacity to empirically test such hypotheses has been limited. The candidate proposes to devise and implement specific activation paradigms to probe discrete parallel cortico-striatal circuits individually, using positron emission tomography (PET) to study adult subjects. In addition to activation studies to determine the mediating neuroanatomy of TS and OCD, receptor characterization techniques will be employed to explore possible neurochemical abnormalities within the striatum. Such a multifaceted approach to the study of cortico-striatal circuits promises to yield important information about OCD, TS, and the physiological functions of cortico-striatal systems.